Relevance. The aim of this study was to determine the correlation of indicators of nitric oxide and oxidative stress of the lacrimal fluid with the severity of non-proliferative diabetic retinopathy. Materials and methods. Clinical studies were conducted during the treatment of 36 patients (69 eyes) diagnosed with non-proliferative diabetic retinopathy (NDR). Patients underwent a general ophthalmological examination and biochemical studies of the lacrimal fluid. Results. Studies have shown a gradual decrease in nitric oxide levels as DR worsens. In patients with NDR 1a severity, the level of nitric oxide decreased statistically significantly by 22.3% (P<0.001), and in 1c severity this level decreased by 66.7% (P<0.001) relative to the values of practically healthy individuals and by 57.1% (P<0.001) compared with the indices of patients with 1a NDR severity. Conclusion. The severity of NDR is directly related to the level of nitric oxide in the lacrimal fluid of patients: as the content of nitric oxide decreases, progression of retinopathy is observed. The imbalance in the POL-AOS system has a staged character.
| Mualliflar | Guzal Kangilbaeva, Ф. А. Бахритдинова, Ф. М. Урманова |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-02-22 |
| Jild | 1 |
| Son | 1 |
| Betlar | 113-116 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.1.1.026 |
DOI: 10.57231/j.ao.2023.1.1.026 · Maqolaning asl sahifasi · PDF
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