Relevance. Despite modern advances in medicine, type 2 diabetes mellitus (DM 2) still remains an important medical and social problem due to the frequency and severity of complications. The purpose of our study. The aim of the study was to evaluate the relationship between the levels of vascular growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) in blood serum and the area of the foveal avascular zone (FAZ) on OCT-A in patients with type 2 diabetes mellitus (DM2), with various stages DR. Materials and methods. A clinical study was conducted among 252 people (n=504), of which 168 patients with type 2 diabetes and 84 practically healthy individuals, the average age of which was 57.6 ± 7.8 years, of which 52.6% were men, 47.4% women. Results. As a result of the studies, an increase in the level of VEGF in the blood serum before the onset of DR clinically was revealed 137.2 ± 84.4 pg/ml (group II of comparison). It was found that the level of VEGF correlated with the levels of BDNF in the serum of patients and with the stage of retinopathy (p<0.05). Based on the studies performed, it was suggested that a mild deficiency with plasma BDNF less than 0.62 ng/ml indicates DR in general, and a BDNF level < 0.22 ng/ml indicates the development of PDR and/or diabetic macular ischemia (DME). Thus, a low level of BDNF and a high level of VEGF in serum can be potential risk factors for DR in T2 DM and serve as its diagnostic indicators.
| Mualliflar | Ф. М. Урманова, Ф. А. Бахритдинова, А. А. Ахраров, Guzal Kangilbaeva |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-02-22 |
| Jild | 1 |
| Son | 1 |
| Betlar | 170-173 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.1.1.039 |
DOI: 10.57231/j.ao.2023.1.1.039 · Maqolaning asl sahifasi · PDF
Relevance. The aging of the Earth’s population is an urgent demographic and medical and social problem that requires the provision of high-quality medical and social solutions. In the Fergana Valley, the population aged…
Relevance. Optic neuropathy is a group of intensively developing degenerative diseases with dysfunction of the optic nerve, diagnosed late, ending in many cases with atrophy due to treatment failure. The purpose of this…
Vascular diseases of the organs of vision are one of the main causes of loss of eye function. There is an inextricable link between ophthalmic pathology and vertebral artery disease, and the eyeball, with its complex…
Among the most significant ophthalmic diseases, the development, course and outcome of which is directly affected by coronavirus infection, a special place is occupied by COVID‑19 associated cavernous sinus thrombosis…
Relevance. Approximately 1.5% to 5% of patients with closed head injuries have damage to the optic pathways (4–6 per 100,000 population per year). TMS is a new, relatively safe, non-drug method for the treatment of…
Annotation. Endothelial microscopy plays an important role in measuring the density of corneal endothelial cells for clinical diagnosis, clinical studies, as well as in assessing the endothelium before and after…
Diabetik retinopatiya (DR) qandli diabet (QD) bemorlarda ko‘rish o‘tkirligi (KO‘)ni pasaytirib ko‘rlikka olib kelishi mumkin bo‘lgan asorat bo‘lib, vaqtida aniqlanmasligi va o‘tkaziladigan davolash muolajalarini…
Sinus maxillaris — this is the largest of all the paranasal sinuses, which is a large shock-absorbing cavity of the middle zone of the face and its integrity can often be violated when the bones of this area are…
Relevance: It is known that light is a transverse wave. But what? What is their nature? To answer this question,we need to analyze what we know about light. In some cases, light and other electromagnetic radiations…
Relevance. The data available in the scientific literature on the role of cytokines as a special biological system, the function of which is the local regulation of regeneration processes, substantiate the relevance of…