Relevance. The data available in the scientific literature on the role of cytokines as a special biological system, the function of which is the local regulation of regeneration processes, substantiate the relevance of the research task in this direction. Purpose of the study. Clinical monitoring of the level of cytokines in the lacrimal fluid in patients after LASIK and Femto-LASIK operations. Materials and methods. The prospective study included 40 patients (80 eyes) with mild to moderate myopia and complex myopic astigmatism operated on in 2022. During the study, lacrimal fluid was taken and its further biochemical study was performed to determine the level of cytokines IL‑1β, IL‑4, TNF-α. Results. In the main group, the frequency of detection of the cytokine IL‑1β, which is the main pro-inflammatory agent, was 80%, while in the comparative group it was detected in 90% of tear fluid samples. Average IL‑1β values were highest in the LASIK comparison group. Average TNF-α values were also the highest in the comparison group. At the same time, the differences in the average values between the main and comparative groups were statistically significant (p<0.05). Average IL‑4 values were the highest in the main group, where the Femto-LASIK operation was performed. Conclusions. The course of the regenerative process in patients after excimer laser vision correction depends on the concentration of pro-inflammatory cytokines IL-1β and TNF-α and anti-inflammatory cytokine IL-4. Based on this, with a higher level of pro-inflammatory cytokines in the lacrimal fluid, the lengthening of the terms of pain relief and epithelialization after surgery was determined.
| Mualliflar | С Ш Миррахимова, Ф. А. Бахритдинова, С. Х. Назирова, З. Р. Максудова, Б. Б. Хаджимухамедов |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-05-23 |
| Jild | 3 |
| Son | 3 |
| Betlar | 180-184 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.3.3.042 |
DOI: 10.57231/j.ao.2023.3.3.042 · Maqolaning asl sahifasi · PDF
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