Болаларда палатопластикада ёноқ ёғ лахтачасини қўллашнинг функционал ва иммунологик асослилиги

Inoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, Umarov Bakhtiyor Yatgarovich

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

. This study is aimed at a comprehensive assessment of the clinical effectiveness and immune tolerance of using a cheek fat body patch during palatoplasty in children with congenital cleft palate. The purpose of the study was to conduct a comparative analysis of the effectiveness and safety of this method based on healing indicators, the frequency of postoperative complications, as well as immunological and morphofunctional markers of inflammation and regeneration. The study included 72 children aged 9 months to 2 years, divided into two groups: the main group (n=38), in which a cheek fat patch was used, and the control group (n=34), in which the traditional defect closure technique was used. Comparative analysis showed that in patients of the main group, the timing of epithelialization was shorter by an average of 4-5 days, the frequency of fistula formation and purulent complications was reduced by more than 2 times. Systemic inflammation indicators (IL-6 and TNF-α levels) in the main group were statistically significantly lower, and the CD4+/CD8+ index reflected a more balanced immune status. Immunohistochemical examination of tissues showed an increase in VEGF and TGF-β expression in patients of the main group, which indicates enhanced angiogenesis and reparative activity. Thus, applying a cheek fat body patch not only ensures reliable closure of the defect but also contributes to a reduction in the inflammatory load and accelerated tissue restoration. The obtained data confirm the clinical effectiveness and immunological safety of the methodology, justifying its inclusion in the standards for surgical treatment of congenital cleft palate in children.

Maqola ma’lumotlari
MualliflarInoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, Umarov Bakhtiyor Yatgarovich
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-10-30
Jild2
Son3/1
TilO‘zbek
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

cleft palate, fat-filled cheek, immune response, cytokines, VEGF, TGF-β, CD4/CD8, epithelialization, complications, paloplasty., расщелина нёба, лоскут жировой щеки, иммунный ответ, цитокины, VEGF, TGF-β, CD4/CD8, эпителизация, осложнения, палатопластика., танглай ёриғи, ёғли ёноқ лахтаги, иммун жавоб, цитокинлар, ВЕГФ, ТГФ-β, CД4/CД8, эпителизация, асоратлар, палатопластика.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAInoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, & Umarov Bakhtiyor Yatgarovich (2025). БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ. Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12634
GOST (OAK)Inoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, Umarov Bakhtiyor Yatgarovich БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ // Klinik fanlar yilnomasi. – 2025. – T. 2, № 3/1.
MLAInoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, and Umarov Bakhtiyor Yatgarovich. “БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ.” Klinik fanlar yilnomasi, 2(3/1), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12634
ChicagoInoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, and Umarov Bakhtiyor Yatgarovich. “БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ.” Klinik fanlar yilnomasi, 2(3/1) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12634
HarvardInoyatov Amrillo Shodiyevich, Rajamatov Timur Rakhimdjanovich, and Umarov Bakhtiyor Yatgarovich (2025) ‘БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ’, Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12634
BibTeX
@article{inoyatovamrilloshodiyevich2025,
  title = {БОЛАЛАРДА ПАЛАТОПЛАСТИКАДА ЁНОҚ ЁҒ ЛАХТАЧАСИНИ ҚЎЛЛАШНИНГ ФУНКЦИОНАЛ ВА ИММУНОЛОГИК АСОСЛИЛИГИ},
  author = {Inoyatov Amrillo Shodiyevich and Rajamatov Timur Rakhimdjanovich and Umarov Bakhtiyor Yatgarovich},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {3/1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12634}
}

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