Development of gastropathy against the background of nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis against the background of virulent genes of helicobacter pylori

Tukhtaeva N.Kh, Musayev H.N

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

The article provides data on the result of a molecular genetic study of the genotypic characteristics of Helicobacter pylori in the formation of NSAIDs of gastropathy in patients with rheumatoid arthritis. Purpose of the study. Molecular-genetic study of the genotypic features of H. pylori in the formation of NSAID gastropathy in RA patients for the prevention of gastroduodenal lesions. Materials and research methods. The research is based on the genomic DNA of H. pylori, isolated from a biopsy of the antrum of 82 patients with RA and 22 healthy individuals. The genotype of H. pylori CagA, vacam1, vacam2, vacAs1, vacas2, vacas1b, vacas1c, icea1, icea2, HP was determined in biopsy samples. Results. Thus, according to the molecular genetic study, the pathogenic strain VacA m2 (х2=4,12 р=0.011), IceA 2 (=6,71 р=0.036) prevails in patients with RA of the 2nd degree of activity. Conclusion. Our preliminary results suggest that the H. Pylori vaca m2 and icea 2 may be considered as additional markers of NSAID-gastropathy in rheumatoid arthritis.

Maqola ma’lumotlari
MualliflarTukhtaeva N.Kh, Musayev H.N
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-10-30
Jild2
Son3/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

. Pylori, rheumatoid arthritis, gastropathies, pcr, molecular genetic study, H. pylori, ревматоидный артрит, гастропатия, пцр, молекулярно-генетическое исследование

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APATukhtaeva N.Kh, & Musayev H.N (2025). DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI. Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12631
GOST (OAK)Tukhtaeva N.Kh, Musayev H.N DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI // Klinik fanlar yilnomasi. – 2025. – T. 2, № 3/1.
MLATukhtaeva N.Kh, and Musayev H.N. “DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI.” Klinik fanlar yilnomasi, 2(3/1), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12631
ChicagoTukhtaeva N.Kh, and Musayev H.N. “DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI.” Klinik fanlar yilnomasi, 2(3/1) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12631
HarvardTukhtaeva N.Kh, and Musayev H.N (2025) ‘DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI’, Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12631
BibTeX
@article{tukhtaevankh2025,
  title = {DEVELOPMENT OF GASTROPATHY AGAINST THE BACKGROUND OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS AGAINST THE BACKGROUND OF VIRULENT GENES OF HELICOBACTER PYLORI},
  author = {Tukhtaeva N.Kh and Musayev H.N},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {3/1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12631}
}

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