Comparative analysis of morphological changes in the thymus gland as a result of experimental chemotherapy

Rasulova N.R, Temirova N.R

Klinik fanlar yilnomasi · 2025-yil

Annotatsiya

This study investigated the morphological changes in the thymus tissue of white outbred rats after experimental chemotherapy for breast cancer. The research aimed to determine the involutive processes in thymus structure, the ratio of stromal and parenchymal elements, and the immunomorphological characteristics under the influence of paclitaxel. Following paclitaxel administration, a decrease in lymphocyte numbers within thymic follicles, thinning of the cortical zone, an increase in macrophages and reticular cells in the medulla, condensation of stromal fibers, and the appearance of adipose tissue elements were observed. In conclusion, chemotherapy induces significant immunodepressive and involutive morphological changes in the thymus, which may reduce the organism’s immune response.

Maqola ma’lumotlari
MualliflarRasulova N.R, Temirova N.R
JurnalKlinik fanlar yilnomasi
NashriyotБухоро давлат тиббиёт институти
ISSN2025-2026, 0009-0006
Nashr sanasi2025-10-30
Jild2
Son3/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

breast cancer, chemotherapy, thymus, paclitaxel, morphology, immunohistochemistry, рак молочной железы, химиотерапия, тимус, паклитаксел, морфология, иммуногистохимия, sut bezi saratoni, kimyoterapiya, ayrisimon bez, paklitaksel, morfologiya, immunogistokimyo

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARasulova N.R, & Temirova N.R (2025). COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY. Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12628
GOST (OAK)Rasulova N.R, Temirova N.R COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY // Klinik fanlar yilnomasi. – 2025. – T. 2, № 3/1.
MLARasulova N.R, and Temirova N.R. “COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY.” Klinik fanlar yilnomasi, 2(3/1), 2025. https://tadqiqot.uz/index.php/spjacd/article/view/12628
ChicagoRasulova N.R, and Temirova N.R. “COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY.” Klinik fanlar yilnomasi, 2(3/1) (2025). https://tadqiqot.uz/index.php/spjacd/article/view/12628
HarvardRasulova N.R, and Temirova N.R (2025) ‘COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY’, Klinik fanlar yilnomasi, 2(3/1). https://tadqiqot.uz/index.php/spjacd/article/view/12628
BibTeX
@article{rasulovanr2025,
  title = {COMPARATIVE ANALYSIS OF MORPHOLOGICAL CHANGES IN THE THYMUS GLAND AS A RESULT OF EXPERIMENTAL CHEMOTHERAPY},
  author = {Rasulova N.R and Temirova N.R},
  journal = {Klinik fanlar yilnomasi},
  year = {2025},
  volume = {2},
  number = {3/1},
  url = {https://tadqiqot.uz/index.php/spjacd/article/view/12628}
}

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