Features of the gut microbiome in patients with parkinson’s disease

Мансурова Наргиза Асроровна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2026-yil

Annotatsiya

Parkinson’s disease is a chronic progressive neurodegenerative disorder characterized not only by motor symptoms but also by pronounced non-motor manifestations, among which gastrointestinal dysfunction plays a significant role. In recent years, increasing attention has been paid to the role of the gut microbiome and the gut–brain axis in the pathogenesis and progression of Parkinson’s disease. The aim of this study was to investigate the characteristics of the gut microbiome in patients with Parkinson’s disease and to assess its relationship with clinical manifestations of the disease. The study included patients with Parkinson’s disease who underwent clinical evaluation of motor and non-motor symptoms using the UPDRS and Hoehn and Yahr scales, as well as analysis of the gut microbiome status with assessment of microbial load, structure of the microbiotic core, and signs of dysbiosis. The results demonstrated significant alterations in the gut microbiome composition, characterized by a reduction in obligate microbiota and an increase in opportunistic microorganisms, which were associated with disease duration and severity of clinical manifestations. These findings confirm the important role of the gut microbiome in mechanisms of neuroinflammation and progression of Parkinson’s disease and substantiate the need to consider it in the development of diagnostic and therapeutic approaches.

Maqola ma’lumotlari
MualliflarМансурова Наргиза Асроровна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2026-03-31
Jild7
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

болезнь Паркинсона, кишечный микробиом, дисбиоз, ось «кишечник–мозг», нейровоспаление, немоторные симптомы, Parkinson’s disease, gut microbiome, dysbiosis, gut–brain axis, neuroinflammation, non-motor symptoms, Parkinson kasalligi, ichak mikrobiomi, disbioz, «ichak–miya» o‘qi, neyroyallig‘lanish, nomotor simptomlar.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAМансурова Наргиза Асроровна (2026). FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1). https://tadqiqot.uz/index.php/neurology/article/view/13357
GOST (OAK)Мансурова Наргиза Асроровна FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2026. – T. 7, № 1.
MLAМансурова Наргиза Асроровна. “FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1), 2026. https://tadqiqot.uz/index.php/neurology/article/view/13357
ChicagoМансурова Наргиза Асроровна. “FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1) (2026). https://tadqiqot.uz/index.php/neurology/article/view/13357
HarvardМансурова Наргиза Асроровна (2026) ‘FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 7(1). https://tadqiqot.uz/index.php/neurology/article/view/13357
BibTeX
@article{article2026,
  title = {FEATURES OF THE GUT MICROBIOME IN PATIENTS WITH PARKINSON’S DISEASE},
  author = {Мансурова Наргиза Асроровна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2026},
  volume = {7},
  number = {1},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/13357}
}

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