Immunological and neurospecific biomarkers in the differential diagnosis of parkinson’s disease and vascular parkinsonism

MANSUROVA Nargiza Asrorovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

The aim of our study was to investigate the features of systemic inflammatory response and central neurospecific damage in patients with Parkinson's disease and vascular parkinsonism to verify differential diagnostic criteria. A comprehensive clinical and laboratory examination of patients with degenerative and vasogenic forms of parkinsonism was performed. All patients underwent neurological testing using international scales. The immunological profile was assessed by serum levels of interleukin-6 and S100 protein using enzyme-linked immunosorbent assay (ELISA). Intestinal status and infectious trigger were verified by fecal calprotectin excretion and -urea breath test results. In Parkinson's disease, an extensive network of interrelations between interleukin-6, gastrointestinal factors, motor deficit, and non-motor burden was revealed, confirming the activity of the gut-brain axis. Serum hyperconcentration of S100 protein was recorded exclusively in the cohort of patients with Parkinson's disease at advanced stages of the process. In the vascular parkinsonism group, markers of systemic inflammation demonstrated pathogenetic autonomy from enteral triggers, with a complete absence of elevated S100 protein cases. Combined monitoring of interleukin-6 and S100 protein allows distinguishing between primary degenerative and secondary vasogenic forms of parkinsonism.

Maqola ma’lumotlari
MualliflarMANSUROVA Nargiza Asrorovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-06
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

болезнь Паркинсона, сосудистый паркинсонизм, интерлейкин-6, белок S100, ось «кишечник–мозг», нейровоспаление, дифференциальная диагностика, Parkinson's disease, vascular parkinsonism, interleukin-6, S100 protein, gut-brain axis, neuroinflammation, differential diagnosis, Parkinson kasalligi, tomir parkinsonizmi, interleykin-6, S100 oqsili, «ichak–miya» o‘qi, neyroyallig‘lanish, differensial diagnostika

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMANSUROVA Nargiza Asrorovna (2026). IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14760
GOST (OAK)MANSUROVA Nargiza Asrorovna IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLAMANSUROVA Nargiza Asrorovna. “IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14760
ChicagoMANSUROVA Nargiza Asrorovna. “IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14760
HarvardMANSUROVA Nargiza Asrorovna (2026) ‘IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14760
BibTeX
@article{mansurovanargizaasrorovna2026,
  title = {IMMUNOLOGICAL AND NEUROSPECIFIC BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF PARKINSON’S DISEASE AND VASCULAR PARKINSONISM},
  author = {MANSUROVA Nargiza Asrorovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14760}
}

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