Short bowel syndrome (SBS) is a severe form of chronic intestinal failure resulting from significant reduction of the small intestinal length and impaired digestion and nutrient absorption. The aim of this literature review is to systematize current knowledge on the pathogenesis, clinical manifestations, diagnosis, and treatment principles of SBS in both adults and children. The review highlights mechanisms of intestinal adaptation, the role of gut microbiota, biochemical and hormonal alterations, as well as modern approaches to nutritional support, including parenteral nutrition and the use of GLP-2 analogs. Special attention is given to a multidisciplinary approach and emerging perspectives in intestinal transplantation and regenerative medicine. Early diagnosis and comprehensive management significantly improve patient outcomes and quality of life.
| Mualliflar | YUNUSALIYEVA Umida Rakhidin kizi, DUSTMUKHAMEDOVA Dinora Xamidovna, UMARNAZAROVA Zulxumor Ernazarovna, KAMILOVA Altinoy Tursunbayevna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-08-06 |
| Jild | 11 |
| Son | 3 |
| Til | Rus |
синдром короткой кишки, кишечная недостаточность, мальабсорбция, парентеральное питание, кишечная адаптация, short bowel syndrome, intestinal failure, malabsorption, parenteral nutrition, intestinal adaptation, qisqa ichak sindromi, ichak yetishmovchiligi, malabsorbsiya, parenteral oziqlantirish, ichak adaptatsiyasi
TORCH infections occupy a leading place among the causes of perinatal pathology and neuropsychological developmental disorders in early childhood. Intrauterine infection has an adverse effect on the formation of the…
Baseline factor VIII activity level cannot serve as a reliable clinical predictor of inhibitor development. Given the high frequency of this complication, regular laboratory screening for antibodies is justified for all…
Purpose: To determine the relationship between blood biochemical parameters (glucose, liver enzymes - ALT/AST, total bilirubin, and cholesterol) and cognitive and psychoemotional status, as well as rehabilitation…
Troponin determination as a biochemical marker of cardiomyocyte necrosis is currently of great importance in cardiology. The aim of this study was to determine markers of myocardial injury and identify the most…
The study results indicate pronounced territorial differences in the physical development indicators of children depending on their place of residence. Children living in rural areas differed from urban schoolchildren…
Early diagnosis of primary open-angle glaucoma plays a key role in preventing irreversible vision loss and slowing the progression of the disease. Despite the widespread use of modern diagnostic methods in developed…
Delayed psycho-speech development (DPSD) in children remains one of the most pressing problems in pediatric neurology due to its high prevalence and significant impact on social adaptation. The aim of the study was to…
Purpose of study: to evaluate the clinical and immunohistochemical characteristics of the upper eyelid skin in women with blepharochalasis from different age-hormonal groups based on the expression levels of estrogen…
The aim of our study was to investigate the features of systemic inflammatory response and central neurospecific damage in patients with Parkinson's disease and vascular parkinsonism to verify differential diagnostic…
Aim: To analyze contemporary data on chemotherapy-induced leukopenia with a focus on the relationship between bone marrow myelogram parameters and peripheral blood indices, and to assess how accurately peripheral blood…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar