Clinical and immunohistochemical changes in the upper eyelid in blepharochalasis in women of different age and hormonal groups

KADIROVA Aziza Muratovna, KHAKIMOVA Mavluda Shavkatjonovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Purpose of study: to evaluate the clinical and immunohistochemical characteristics of the upper eyelid skin in women with blepharochalasis from different age-hormonal groups based on the expression levels of estrogen receptors ER-α and ER-β. Materials and methods: after standart ophthalmological examination, 90 patients with blepharochalasis aged 24 to 67 years were divided into three groups according to age and hormonal status. Additionally, all patients underwent assessment of the condition of the upper eyelid skin, biopsy sampling, and immunohistochemical examination using monoclonal antibodies against estrogen receptors ER-α and ER-β. The level of receptor expression was evaluated using the H-score method. Results: the mean ER-α expression level in patients of reproductive age was 78.4±4.6, in the perimenopausal group 61.2±3.9, and in the postmenopausal group 44.7±3.2. A similar trend was observed for ER-β expression: 72.9±4.1, 58.6±3.4, and 39.5±2.8, respectively. Analysis of variance revealed statistically significant differences between the studied groups in the expression levels of ER-α (p=0.0003) and ER-β (p=0.0001). Conclusion: the obtained results indicate a decrease in estrogen receptor expression with increasing patient age and confirm the involvement of hormonal factors in the development of blepharochalasis.

Maqola ma’lumotlari
MualliflarKADIROVA Aziza Muratovna, KHAKIMOVA Mavluda Shavkatjonovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-06
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

блефарохалязис, верхнее веко, иммуногистохимия, ER-α, ER-β, рецепторы эстрогена, менопауза., blepharochalasis, upper eyelid, immunohistochemistry, ER-α, ER-β, estrogen receptors, menopause.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKADIROVA Aziza Muratovna, & KHAKIMOVA Mavluda Shavkatjonovna (2026). CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14749
GOST (OAK)KADIROVA Aziza Muratovna, KHAKIMOVA Mavluda Shavkatjonovna CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLAKADIROVA Aziza Muratovna, and KHAKIMOVA Mavluda Shavkatjonovna. “CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14749
ChicagoKADIROVA Aziza Muratovna, and KHAKIMOVA Mavluda Shavkatjonovna. “CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14749
HarvardKADIROVA Aziza Muratovna, and KHAKIMOVA Mavluda Shavkatjonovna (2026) ‘CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14749
BibTeX
@article{kadirovaazizamuratovna2026,
  title = {CLINICAL AND IMMUNOHISTOCHEMICAL CHANGES IN THE UPPER EYELID IN BLEPHAROCHALASIS IN WOMEN OF DIFFERENT AGE AND HORMONAL GROUPS},
  author = {KADIROVA Aziza Muratovna and KHAKIMOVA Mavluda Shavkatjonovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14749}
}

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