Pathogenetic foundations and evaluation of clinical efficacy of probiotic therapy in the complex treatment of superficial bladder cancer

NISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, BABAKULOVA Shahlo Xamidullayevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

The study involved 212 patients with superficial bladder cancer (NMIBC). The objective was to evaluate the impact of perioperative probiotic therapy (Lactobacillus acidophilus and E. coli M17) on urothelial regeneration and local immune status (CD8+, Ki-67). The results demonstrated that correcting immunological imbalance via probiotics significantly reduces recurrence rates. The developed 24-parameter mathematical model allows for the prediction of recurrence risk with an accuracy of over 85%.

Maqola ma’lumotlari
MualliflarNISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, BABAKULOVA Shahlo Xamidullayevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-05
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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Kalit so‘zlar

Поверхностный рак мочевого пузыря, пробиотикотерапия, трансуретральная резекция, репаративная регенерация, локальный иммунитет, иммуногистохимия, Ki-67, CD8+, математическая модель прогнозирования, Non-muscle-invasive bladder cancer, probiotic therapy, transurethral resection, reparative regeneration, local immunity, immunohistochemistry, Ki-67, CD8+, mathematical prediction model, Yuza qovuq saratoni, probiotikoterapiya, transuretral rezeksiya, reparatitv regeneratsiya, mahalliy immunitet, immunogistoximiya, Ki-67, CD8+, matematik bashoratlash modeli.

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Iqtibos keltirish

APANISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, & BABAKULOVA Shahlo Xamidullayevna (2026). PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14747
GOST (OAK)NISHONOV Doniyor Anarboyevich va b. PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLANISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, and BABAKULOVA Shahlo Xamidullayevna. “PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14747
ChicagoNISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, and BABAKULOVA Shahlo Xamidullayevna. “PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14747
HarvardNISHONOV Doniyor Anarboyevich, BABAKULOV Sharaf Xamrakulovich, NAVRUZOVA Visola Sarimbekovna, SULAYMANOVA Nodira Jumayevna, and BABAKULOVA Shahlo Xamidullayevna (2026) ‘PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14747
BibTeX
@article{nishonovdoniyoranarboyevich2026,
  title = {PATHOGENETIC FOUNDATIONS AND EVALUATION OF CLINICAL EFFICACY OF PROBIOTIC THERAPY IN THE COMPLEX TREATMENT OF SUPERFICIAL BLADDER CANCER},
  author = {NISHONOV Doniyor Anarboyevich and BABAKULOV Sharaf Xamrakulovich and NAVRUZOVA Visola Sarimbekovna and SULAYMANOVA Nodira Jumayevna and BABAKULOVA Shahlo Xamidullayevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14747}
}

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