The value of quantitative MRI methods (diffusion tensor imaging) in the early diagnosis of the preclinical stage of binswanger's disease

ADAMBOYEV Zufar Ibrohimovich, SAMIYEV Asliddin Sayitovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective:To study the diagnostic significance of quantitative indices of diffusion tensor imaging (DTI) for detecting microstructural changes in white matter at the preclinical stage of BD. Relevance. Binswanger's disease (BD) is accompanied by progressive cognitive decline. Standard MRI (T1/T2 modes) reveals white matter changes (leukoaraiosis) only at late stages, when treatment is already ineffective. Materials and Methods. The study involved 60 patients (55–70 years old) with arterial hypertension and cognitive complaints but without dementia. All underwent standard MRI and DTI tractography, analyzing fractional anisotropy (FA) and mean diffusivity (MD). Results. In most patients, standard MRI showed minimal changes; however, DTI revealed a statistically significant decrease in FA and an increase in MD in the frontal lobes and internal capsule. These changes correlated with impaired executive functions during neuropsychological testing. Conclusion. DTI is a highly sensitive method that allows for the diagnosis of preclinical white matter disorganization. The use of DTI metrics reveals BD before the formation of pronounced leukoaraiosis, opening opportunities for timely therapy.

Maqola ma’lumotlari
MualliflarADAMBOYEV Zufar Ibrohimovich, SAMIYEV Asliddin Sayitovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-06
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

болезнь Бинсвангера, сосудистая когнитивная недостаточность, диффузионно-тензорная визуализация, фракционная анизотропия, лейкоареоз, ранняя диагностика, Binswanger's disease, vascular cognitive impairment, diffusion tensor imaging, fractional anisotropy, leukoaraiosis, early diagnosis, Binsvanger kasalligi, tomir kognitiv yetishmovchiligi, diffuzion-tenzor vizualizatsiyasi, fraktsional anizotropiya, leykoaraoz, erta tashxis

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAADAMBOYEV Zufar Ibrohimovich, & SAMIYEV Asliddin Sayitovich (2026). THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14762
GOST (OAK)ADAMBOYEV Zufar Ibrohimovich, SAMIYEV Asliddin Sayitovich THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLAADAMBOYEV Zufar Ibrohimovich, and SAMIYEV Asliddin Sayitovich. “THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14762
ChicagoADAMBOYEV Zufar Ibrohimovich, and SAMIYEV Asliddin Sayitovich. “THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14762
HarvardADAMBOYEV Zufar Ibrohimovich, and SAMIYEV Asliddin Sayitovich (2026) ‘THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14762
BibTeX
@article{adamboyevzufaribrohimovich2026,
  title = {THE VALUE OF QUANTITATIVE MRI METHODS (DIFFUSION TENSOR IMAGING) IN THE EARLY DIAGNOSIS OF THE PRECLINICAL STAGE OF BINSWANGER'S DISEASE},
  author = {ADAMBOYEV Zufar Ibrohimovich and SAMIYEV Asliddin Sayitovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14762}
}

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