Application of l-prf technology in the comprehensive surgical treatment of medication-related osteonecrosis of the jaws

RIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, NORMURADOV Nodirjon Alisherovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

A retrospective study included 30 patients with stage II MRONJ: 20 patients underwent surgical treatment with L-PRF, while 10 patients received conventional surgical treatment without L-PRF. The groups were comparable in terms of sex, age, lesion localization, and type of antiresorptive therapy. The aim of the study was to evaluate the clinical efficacy of L-PRF as an adjunctive component of comprehensive surgical treatment for patients with medication-related osteonecrosis of the jaws. In the main group, complete mucosal healing after 30 days was achieved in 100% of patients, compared with 70.0% in the control group (p=0.029). No postoperative complications were observed in the L-PRF group, whereas they occurred in 30.0% of patients receiving conventional treatment (p=0.029). The mean healing time was 30.0±0.0 versus 42.0±8.0 days, respectively (p=0.001), confirming the effectiveness of L-PRF in accelerating epithelialization and reducing complications.

Maqola ma’lumotlari
MualliflarRIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, NORMURADOV Nodirjon Alisherovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-06
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

медикаментозно-ассоциированный остеонекроз челюстей, MАOНЧ, L-PRF, тромбоцитарно-обогащённый фибрин, секвестрэктомия, регенерация, челюстно-лицевая хирургия., medication-related osteonecrosis of the jaws, MRONJ, L-PRF, platelet-rich fibrin, sequestrectomy, regeneration, maxillofacial surgery, jag‘larning medikamentoz-assotsiatsiyalangan osteonekrozi, JMАON, L-PRF, trombotsitar boyitilgan fibrin, sekvestrektomiya, regeneratsiya, yuz-jag‘ jarrohligi

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Iqtibos keltirish

APARIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, & NORMURADOV Nodirjon Alisherovich (2026). APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14767
GOST (OAK)RIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, NORMURADOV Nodirjon Alisherovich APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLARIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, and NORMURADOV Nodirjon Alisherovich. “APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14767
ChicagoRIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, and NORMURADOV Nodirjon Alisherovich. “APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14767
HarvardRIZAEV Jasur Alimdjanovich, ZAYNUTDINOV Muradilla Omonullaevich, and NORMURADOV Nodirjon Alisherovich (2026) ‘APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14767
BibTeX
@article{rizaevjasuralimdjanovich2026,
  title = {APPLICATION OF L-PRF TECHNOLOGY IN THE COMPREHENSIVE SURGICAL TREATMENT OF MEDICATION-RELATED OSTEONECROSIS OF THE JAWS},
  author = {RIZAEV Jasur Alimdjanovich and ZAYNUTDINOV Muradilla Omonullaevich and NORMURADOV Nodirjon Alisherovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14767}
}

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