Comparison of methods for detecting kappa free light chains and oligoclonal bands in cerebrospinal fluid for the diagnosis of multiple sclerosis

Абдулазизова Умидахон Салохиддин кизи, Мусаева Юлдуз Альписовна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

The aim of this study was to evaluate the diagnostic accuracy of detecting kappa free light chains (KFLC) in cerebrospinal fluid for the diagnosis of multiple sclerosis, in comparison with isoelectric focusing (IEF) for detecting oligoclonal bands (OCB) as the reference standard. A total of 64 cases were divided into OCB-positive and OCB-negative groups based on OCB results. Diagnostic accuracy was calculated at a threshold of 1 mg/L. The 1 mg/L threshold yielded an agreement rate of 86.1% and a Cohen’s kappa value of 0.8. The Youden index determined 0.92 mg/L as the optimal cutoff value (specificity 90.3% and sensitivity 90.9%). The analytical time was 3 hours 55 minutes for IEF and 25 minutes for KFLC. The KFLC method proved to be an accurate, cost-effective, and rapid alternative that can be applied prior to modern OCB testing.

Maqola ma’lumotlari
MualliflarАбдулазизова Умидахон Салохиддин кизи, Мусаева Юлдуз Альписовна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-11-19
Jild6
Son6/1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

биохимия; иммуноглобулины; рассеянный склероз, biochemistry; immunoglobulins; multiple sclerosis, biokimyo; immunoglobulinlar; tarqoq skleroz

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАбдулазизова Умидахон Салохиддин кизи, & Мусаева Юлдуз Альписовна (2025). COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1). https://tadqiqot.uz/index.php/neurology/article/view/12909
GOST (OAK)Абдулазизова Умидахон Салохиддин кизи, Мусаева Юлдуз Альписовна COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 6/1.
MLAАбдулазизова Умидахон Салохиддин кизи, and Мусаева Юлдуз Альписовна. “COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12909
ChicagoАбдулазизова Умидахон Салохиддин кизи, and Мусаева Юлдуз Альписовна. “COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12909
HarvardАбдулазизова Умидахон Салохиддин кизи, and Мусаева Юлдуз Альписовна (2025) ‘COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6/1). https://tadqiqot.uz/index.php/neurology/article/view/12909
BibTeX
@article{article2025,
  title = {COMPARISON OF METHODS FOR DETECTING KAPPA FREE LIGHT CHAINS AND OLIGOCLONAL BANDS IN CEREBROSPINAL FLUID FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS},
  author = {Абдулазизова Умидахон Салохиддин кизи and Мусаева Юлдуз Альписовна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {6/1},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/12909}
}

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