The role of cytokine imbalance in the pathogenesis of glioblastoma in women

Ulugbekova, Gulruxan J., Mamajonov , Zafar A., Mamatova, Irodaxon Y.

Товарлар кимёси ва халқ табобати · 2025-yil

Annotatsiya

Glioblastoma is the most aggressive form of primary brain tumors and is accompanied by pronounced alterations in the immune microenvironment. In the present study, the serum cytokine profile was analyzed in 18 women with newly diagnosed glioblastoma. The amount of IL-10, IL-1β, IL-6, TNF-α, and IFN-γ were measured by using the ELISA method. The results showed a significant increase in both pro-inflammatory and anti-inflammatory cytokines, reflecting the characteristic immune response imbalance observed in glioblastoma. This cytokine profile confirms the role of chronic inflammation and immunosuppression in the tumor’s pathogenesis and may be considered a promising target for the development of immunomodulatory therapeutic strategies.

Maqola ma’lumotlari
MualliflarUlugbekova, Gulruxan J., Mamajonov , Zafar A., Mamatova, Irodaxon Y.
JurnalТоварлар кимёси ва халқ табобати
NashriyotТабобат академияси
ISSN2181-2977
Nashr sanasi2025-12-04
Jild4
Son4
TilIngliz
Ilmiy sohaTibbiyot
DOI10.55475/jcgtm/vol4.iss4.2025.543
Indeksga qo‘shilgan2026-08-26

DOI: 10.55475/jcgtm/vol4.iss4.2025.543 · Maqolaning asl sahifasi

Kalit so‘zlar

Glioblastoma, cytokines, IL-6, IL-10, TNF-α, IFN-γ, pathogenesis, immunosuppression., 1-(2-карбоксифенил)-1'-N-метилоксиферроценилтиоамид, glioblastoma, sitokinlar, IL-6, IL-10, TNF-α, IFN-γ, patogenez, immunosupressiya.

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUlugbekova, Gulruxan J., Mamajonov , Zafar A., & Mamatova, Irodaxon Y. (2025). THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN. Товарлар кимёси ва халқ табобати, 4(4). https://doi.org/10.55475/jcgtm/vol4.iss4.2025.543
GOST (OAK)Ulugbekova, Gulruxan J., Mamajonov , Zafar A., Mamatova, Irodaxon Y. THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN // Товарлар кимёси ва халқ табобати. – 2025. – T. 4, № 4. – DOI: 10.55475/jcgtm/vol4.iss4.2025.543.
MLAUlugbekova, Gulruxan J., Mamajonov , Zafar A., and Mamatova, Irodaxon Y. “THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN.” Товарлар кимёси ва халқ табобати, 4(4), 2025. https://doi.org/10.55475/jcgtm/vol4.iss4.2025.543
ChicagoUlugbekova, Gulruxan J., Mamajonov , Zafar A., and Mamatova, Irodaxon Y. “THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN.” Товарлар кимёси ва халқ табобати, 4(4) (2025). https://doi.org/10.55475/jcgtm/vol4.iss4.2025.543
HarvardUlugbekova, Gulruxan J., Mamajonov , Zafar A., and Mamatova, Irodaxon Y (2025) ‘THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN’, Товарлар кимёси ва халқ табобати, 4(4). https://doi.org/10.55475/jcgtm/vol4.iss4.2025.543
BibTeX
@article{ulugbekovagulruxanj2025,
  title = {THE ROLE OF CYTOKINE IMBALANCE IN THE PATHOGENESIS OF GLIOBLASTOMA IN WOMEN},
  author = {Ulugbekova, Gulruxan J. and Mamajonov , Zafar A. and Mamatova, Irodaxon Y.},
  journal = {Товарлар кимёси ва халқ табобати},
  year = {2025},
  volume = {4},
  number = {4},
  doi = {10.55475/jcgtm/vol4.iss4.2025.543},
  url = {https://doi.org/10.55475/jcgtm/vol4.iss4.2025.543}
}

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