This article explores the immunotherapeutic significance of the enzyme NTPDase 8 in oncology. In recent years, immunotherapy has emerged as a promising approach in the fight against cancer, highlighting the growing need to understand the complex interactions within the tumor microenvironment (TME). NTPDase 8 belongs to the family of ectonucleotidases involved in the metabolism of extracellular nucleotides and is predominantly expressed in the liver. The article discusses in detail the role of NTPDase 8 in cancer biology, its immunomodulatory functions, and its potential as a therapeutic target in cancer immunotherapy. Additionally, the pharmacological modulation of NTPDase 8 and directions for future research are considered. In conclusion, NTPDase 8 represents a promising target in cancer immunotherapy, and its further investigation may contribute to the development of novel targeted therapeutic strategies
| Mualliflar | Askarov, Ibragim R., Mamatova, Iroda Yu., Tadjibaeva, Mohinur A. |
|---|---|
| Jurnal | Товарлар кимёси ва халқ табобати |
| Nashr sanasi | 2025-03-26 |
| Jild | 3 |
| Son | 6 |
| Betlar | 364-380 |
| Til | O‘zbek |
| DOI | 10.55475/jcgtm/vol3.iss6.2024.468 |
DOI: 10.55475/jcgtm/vol3.iss6.2024.468 · Maqolaning asl sahifasi
NTPDase 8, immunotherapy, oncology, tumor microenvironment, ectonucleotidases, НТФдаза 8, иммунотерапия, онкология, микросреда опухоли, экто-нуклеотидазы, NTPdaza 8, immunoterapiya, onkologiya, oʼsimta mikromuhiti, ektonukleotidazalar
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