Introduction. Intracranial meningiomas are the most common primary brain tumors and exhibit substantial clinical and biological heterogeneity. Over the last two decades, management paradigms have shifted: alongside surgical resection, stereotactic radiosurgery, fractionated radiotherapy, and active surveillance have gained increasing importance, particularly for small asymptomatic lesions. Materials and Methods. A retrospective analytical review of population-based cohorts and large oncologic registries was performed. Demographics, tumor characteristics (size, WHO grade), clinical status, treatment strategy (observation, surgery, radiotherapy, combined approaches), and survival-related factors were assessed using descriptive statistics, multivariable regression models, and survival analyses. Results. The cohort was predominantly female, and most tumors were WHO grade I. Over time, an increase in active surveillance and a relative decrease in surgical treatment rates were observed, particularly among patients with small tumors. Surgery remained the primary modality for large and symptomatic lesions, whereas radiosurgery and adjuvant radiotherapy were applied selectively, mainly for challenging skull-base locations, subtotal resection, and WHO grade II–III tumors. Older age, higher comorbidity burden, larger tumor size, and higher grade were associated with worse outcomes. Conclusion. Current intracranial meningioma management is increasingly driven by a personalized, multidisciplinary strategy integrating clinical, radiological, and molecular-genetic parameters (within the WHO 2021 framework) to optimize risk stratification, tailor surgical extent, and justify radiotherapy or surveillance.
| Mualliflar | Ravshanov Davron Mavlonovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-08-05 |
| Jild | 11 |
| Son | 3 |
| Til | Rus |
внутричерепная менингиома; нейрохирургия; стереотаксическая радиохирургия; лучевая терапия; активное наблюдение; WHO 2021; молекулярные маркеры; прогноз; выживаемость, intracranial meningioma; neurosurgery; stereotactic radiosurgery; radiotherapy; active surveillance; WHO 2021; molecular markers; prognosis; survival, bosh miya ichidagi meningioma; neyroxirurgiya; stereotaksik radiojarrohlik; nurlanish terapiyasi; faol kuzatuv; WHO 2021; molekulyar markerlar; prognoz; omon qolish
Introduction. Spinal meningiomas are among the most common benign tumors of the spinal canal and are frequently associated with neurological deficits due to spinal cord compression. Although surgical resection is highly…
This article is based on the results of an experimental scientific study conducted on 120 six-month-old outbred white rats. During the study, morphological changes in the adrenal glands were identified in rats exposed…
Acute ischemic stroke remains a leading cause of mortality and long-term disability worldwide despite significant advances in reperfusion therapy. Modern endovascular treatment, particularly mechanical thrombectomy, has…
Regardless of the cause of the enlargement of the nasal concha, difficulty in breathing through the nose and other symptoms of the disease lead to a change in the quality of life of patients, which forces them to…
Cervical cancer (CC) remains one of the most serious threats to women’s health, particularly in low- and middle-income countries, where late-stage diagnosis continues to be associated with high mortality rates…
Surgical treatment of children with adenoid vegetations is currently one of the most relevant topics in modern otorhinolaryngology. The aim of the study is to evaluate the results of cytological examination of…
Objective. To comparatively evaluate the clinical effectiveness, safety, and clinical-economic advantages of the Sentimag + Magtrace magnetic navigation system for sentinel lymph node detection in stage II–III breast…
Otomycosis (fungal otitis externa) is usually characterized as a fungal infection of the external auditory canal, but in rare cases, it can also be complicated by the middle ear. Although it is not life-threatening, it…
Cervical diseases, including precancerous lesions, remain a major challenge in modern gynecology and gynecologic oncology. Despite the introduction of screening programs, cervical cancer remains a leading cause of…
This study examined the diagnostic significance of transferrin and ceruloplasmin levels in oral fluid (OF) for diagnosing the secretory stage of exudative otitis media (EOM) in children aged 1–5 years. The study…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar