This study examined the diagnostic significance of transferrin and ceruloplasmin levels in oral fluid (OF) for diagnosing the secretory stage of exudative otitis media (EOM) in children aged 1–5 years. The study included 77 children with EMA and chronic adenoiditis (main group), 60 children without EMA and without adenoid hypertrophy (comparison group), and 35 healthy children (control group). It was found that in the main group, the level of transferrin in the middle ear fluid was 4 times higher than normal (12.4 ± 1.1 mg/L), and the level of ceruloplasmin was also 4 times higher (4.8 ± 0.5 mg/L). A strong positive correlation (r = 0.74; p < 0.01) was identified between transferrin levels and exudate viscosity. When transferrin levels >12 mg/L are combined with sIgA <0.12 g/L, the risk of developing “sticky ear” increases 4.5-fold. These data allow for the implementation of a non-invasive diagnostic algorithm based on oral fluid biomarkers in clinical practice.
| Mualliflar | NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-08-05 |
| Jild | 11 |
| Son | 3 |
| Til | O‘zbek |
экссудативный средний отит, дети, ротовая жидкость, трансферрин, церулоплазмин, sIgA, окислительный стресс, неинвазивная диагностика, мукозальный иммунитет, exudative otitis media, children, oral fluid, transferrin, ceruloplasmin, sIgA, oxidative stress, non-invasive diagnosis, mucosal immunity, ekssudativ o'rta otit, bolalar, og'iz bo'shlig'i suyuqligi, transferrin, seruloplazmin, sIgA, oksidativ stress, noinvaziv tashxis, mukozal immunitet
Otomycosis (fungal otitis externa) is usually characterized as a fungal infection of the external auditory canal, but in rare cases, it can also be complicated by the middle ear. Although it is not life-threatening, it…
Objective: To conduct a comparative evaluation of the clinical and biochemical efficacy of an optimized three-component treatment regimen for the secretory phase of exudative otitis media (EOM) in children aged 1–5…
Surgical treatment of children with adenoid vegetations is currently one of the most relevant topics in modern otorhinolaryngology. The aim of the study is to evaluate the results of cytological examination of…
Introduction: Chronic cystic sinusitis is accompanied by the depletion of local protective mechanisms. Cystic sinusitis represents one of the most common clinical variants of chronic sinusitis. Paranasal sinus cysts…
Regardless of the cause of the enlargement of the nasal concha, difficulty in breathing through the nose and other symptoms of the disease lead to a change in the quality of life of patients, which forces them to…
Chronic rhinosinusitis (CRS) is a common and clinically significant manifestation of cystic fibrosis in children, influencing the course of pulmonary disease and patients’ quality of life. Dysfunction of the CFTR…
This article is based on the results of an experimental scientific study conducted on 120 six-month-old outbred white rats. During the study, morphological changes in the adrenal glands were identified in rats exposed…
Patients with end-stage renal disease (ESRD) face many complications. One of these complications is damage to the auditory system. Several mechanisms for the development of hearing loss in these patients have been…
Introduction. Intracranial meningiomas are the most common primary brain tumors and exhibit substantial clinical and biological heterogeneity. Over the last two decades, management paradigms have shifted: alongside…
Benign laryngeal neoplasms are among the most common diseases of the upper respiratory tract and are often accompanied by significant functional disorders of the vocal apparatus, reducing patients’ quality of life…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar