Stage-by-stage diagnosis of exudative otitis media in children based on transferrin and ceruloplasmin levels in oral fluid

NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

This study examined the diagnostic significance of transferrin and ceruloplasmin levels in oral fluid (OF) for diagnosing the secretory stage of exudative otitis media (EOM) in children aged 1–5 years. The study included 77 children with EMA and chronic adenoiditis (main group), 60 children without EMA and without adenoid hypertrophy (comparison group), and 35 healthy children (control group). It was found that in the main group, the level of transferrin in the middle ear fluid was 4 times higher than normal (12.4 ± 1.1 mg/L), and the level of ceruloplasmin was also 4 times higher (4.8 ± 0.5 mg/L). A strong positive correlation (r = 0.74; p < 0.01) was identified between transferrin levels and exudate viscosity. When transferrin levels >12 mg/L are combined with sIgA <0.12 g/L, the risk of developing “sticky ear” increases 4.5-fold. These data allow for the implementation of a non-invasive diagnostic algorithm based on oral fluid biomarkers in clinical practice.

Maqola ma’lumotlari
MualliflarNАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-05
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

экссудативный средний отит, дети, ротовая жидкость, трансферрин, церулоплазмин, sIgA, окислительный стресс, неинвазивная диагностика, мукозальный иммунитет, exudative otitis media, children, oral fluid, transferrin, ceruloplasmin, sIgA, oxidative stress, non-invasive diagnosis, mucosal immunity, ekssudativ o'rta otit, bolalar, og'iz bo'shlig'i suyuqligi, transferrin, seruloplazmin, sIgA, oksidativ stress, noinvaziv tashxis, mukozal immunitet

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APANАSRETDINOVА Maxzuna Taxsinovna, & DUSTBOBOEV Dilshod Sadullaevich (2026). STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14733
GOST (OAK)NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLANАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich. “STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14733
ChicagoNАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich. “STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14733
HarvardNАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich (2026) ‘STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14733
BibTeX
@article{nsretdinovmaxzunataxsinovna2026,
  title = {STAGE-BY-STAGE DIAGNOSIS OF EXUDATIVE OTITIS MEDIA IN CHILDREN BASED ON TRANSFERRIN AND CERULOPLASMIN LEVELS IN ORAL FLUID},
  author = {NАSRETDINOVА Maxzuna Taxsinovna and DUSTBOBOEV Dilshod Sadullaevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14733}
}

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