Improvement of diagnostic approaches and conservative treatment of chronic rhinosinusitis in children with cystic fibrosis

KHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, MAKHMUDOVA Saodat Kurbonbekovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Chronic rhinosinusitis (CRS) is a common and clinically significant manifestation of cystic fibrosis in children, influencing the course of pulmonary disease and patients’ quality of life. Dysfunction of the CFTR protein leads to mucus dehydration, impaired mucociliary clearance, and persistent bacterial colonization of the paranasal sinuses. Despite the high prevalence of radiological abnormalities, clinical symptoms in children are often mild or underrecognized, complicating early diagnosis. This review summarizes current approaches to the diagnosis of CRS in children with cystic fibrosis, including symptom-endoscopic and imaging techniques, as well as microbiological and molecular methods. Contemporary strategies of conservative management are analyzed, including irrigation therapy, topical corticosteroids, antibacterial treatment, and CFTR modulators. Particular attention is paid to the need for standardized diagnostic criteria, reduction of systemic antibiotic burden, and development of personalized therapeutic approaches.

Maqola ma’lumotlari
MualliflarKHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, MAKHMUDOVA Saodat Kurbonbekovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-05
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

хронический риносинусит, муковисцидоз, дети, CFTR, мукоцилиарный клиренс, назальный полипоз, диагностика, консервативное лечение, антибиотикотерапия, CFTR-модуляторы, chronic rhinosinusitis, cystic fibrosis, children, CFTR, mucociliary clearance, nasal polyposis, diagnosis, conservative treatment, antibiotic therapy, CFTR modulators, сурункали риносинусит, муковисцидоз, болалар, CFTR, мукоцилиар клиренс, назал полипоз, ташхис, консерватив даволаш, антибиотикотерапия, CFTR-модуляторлар

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, & MAKHMUDOVA Saodat Kurbonbekovna (2026). IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14730
GOST (OAK)KHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, MAKHMUDOVA Saodat Kurbonbekovna IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLAKHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, and MAKHMUDOVA Saodat Kurbonbekovna. “IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14730
ChicagoKHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, and MAKHMUDOVA Saodat Kurbonbekovna. “IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14730
HarvardKHUSHVAKOVA Nilyufar Jurakulovna, KHAMRAKULOVA Nargiza Orzuevna, and MAKHMUDOVA Saodat Kurbonbekovna (2026) ‘IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14730
BibTeX
@article{khushvakovanilyufarjurakulovna2026,
  title = {IMPROVEMENT OF DIAGNOSTIC APPROACHES AND CONSERVATIVE TREATMENT OF CHRONIC RHINOSINUSITIS IN CHILDREN WITH CYSTIC FIBROSIS},
  author = {KHUSHVAKOVA Nilyufar Jurakulovna and KHAMRAKULOVA Nargiza Orzuevna and MAKHMUDOVA Saodat Kurbonbekovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14730}
}

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