Features of metabolic and inflammatory markers in different clinical and laboratory phenotypes of chronic kidney disease in patients with type 2 diabetes mellitus

XAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, DUSHAMOVA Mexribon Shavkatovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective. To evaluate the clinical and laboratory characteristics of four chronic kidney disease (CKD) phenotypes in patients with type 2 diabetes mellitus (T2DM) according to estimated glomerular filtration rate (eGFR) and albuminuria status. Materials and Methods. This prospective cross-sectional study included 153 patients with T2DM stratified into four groups: NRF/NA (normal renal function/normoalbuminuria, n=35), DRF/NA (decreased renal function/normoalbuminuria, n=35), NRF/EA (normal renal function/elevated albuminuria, n=35), and DRF/EA (decreased renal function/elevated albuminuria, n=30). The control group consisted of 18 healthy individuals. Demographic, anthropometric, glycemic, lipid, inflammatory, and coagulation parameters were assessed. Results. The groups differed significantly in age (p<0.001), blood pressure levels, markers of renal function, carbohydrate metabolism indices, and inflammatory parameters. The highest C-reactive protein (CRP) levels (24.5±13.1 mg/L) were observed in the NRF/EA group. In the same group, cystatin C reached 5.79±2.0 mg/L despite formally normal eGFR values. The prothrombin index was significantly elevated in groups with albuminuria. BMP-7 levels did not differ significantly between the groups (p=0.080); however, BMP-7 showed a positive correlation with C-peptide (ρ=0.176; p=0.030). Conclusion. CKD phenotyping in T2DM based on two axes (eGFR and albuminuria) reveals heterogeneity of pathogenic mechanisms, which has practical implications for personalized nephroprotective therapy. The NRF/EA phenotype is characterized by a predominance of pro-inflammatory and procoagulant features accompanied by subclinical tubular dysfunction.

Maqola ma’lumotlari
MualliflarXAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, DUSHAMOVA Mexribon Shavkatovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-04
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

сахарный диабет 2 типа; хроническая болезнь почек; диабетическая нефропатия; BMP-7; цистатин С; альбуминурия; скорость клубочковой фильтрации; С-реактивный белок, type 2 diabetes mellitus; chronic kidney disease; diabetic nephropathy; BMP-7; cystatin C; albuminuria; glomerular filtration rate; C-reactive protein, 2-tip qandli diabet; buyrak surunkali kasalligi; diabetik nefropatiya; BMP-7; sistatin C; albuminuriya; koptokchali filtratsiya tezligi; C-reaktiv oqsil

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAXAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, & DUSHAMOVA Mexribon Shavkatovna (2026). FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14701
GOST (OAK)XAYDAROVA Feruza Alimovna va b. FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLAXAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, and DUSHAMOVA Mexribon Shavkatovna. “FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14701
ChicagoXAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, and DUSHAMOVA Mexribon Shavkatovna. “FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14701
HarvardXAYDAROVA Feruza Alimovna, OYXUDJAYEVA Kamila Farruxovna, ISOMIDDINOV Alijon Olimjon o'g'li, BEGMATOVA Xafiza Ashirmetovna, and DUSHAMOVA Mexribon Shavkatovna (2026) ‘FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14701
BibTeX
@article{xaydarovaferuzaalimovna2026,
  title = {FEATURES OF METABOLIC AND INFLAMMATORY MARKERS IN DIFFERENT CLINICAL AND LABORATORY PHENOTYPES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS},
  author = {XAYDAROVA Feruza Alimovna and OYXUDJAYEVA Kamila Farruxovna and ISOMIDDINOV Alijon Olimjon o'g'li and BEGMATOVA Xafiza Ashirmetovna and DUSHAMOVA Mexribon Shavkatovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14701}
}

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