Optimization of conservative treatment for exudative otitis media in children: the synergistic effect of piln, topical immunocorrection, and play autoinsufflation

NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective: To conduct a comparative evaluation of the clinical and biochemical efficacy of an optimized three-component treatment regimen for the secretory phase of exudative otitis media (EOM) in children aged 1–5 years, comprising low-intensity laser therapy (LILT), topical immunocorrection, and playful autoinsufflation, compared with standard treatment. Methods: 172 children (ages 1–5 years) were examined: subgroup A (n=40) — LI + lysates + autoinsufflation; subgroup B (n=37) — standard treatment; comparison group (n=60); control group (n=35). Salivary biomarkers (transferrin, ceruloplasmin, sIgA, myeloperoxidase), tympanometry data, OEA, and CSVP were assessed every 5 days. Results: In group A, by day 14, the transferrin level decreased 3.2-fold (to 3.8 ± 0.5 mg/L), while sIgA increased 2.3-fold (to 0.28 ± 0.03 g/L; p < 0.001). By day 30, type A tympanogram was restored in 92.5% of children in group A (OR = 7.8; 95% CI 1.9–31.6; p < 0.05) and in 62.2% in group B. The need for adenotomy in Group A decreased by a factor of 4.9 (5% vs. 24.3%). During the 6-month follow-up, recurrence rates were 2.5% in Group A and 18.9% in Group B (p<0.05). Conclusion: The three-component regimen combined with non-invasive monitoring of biomarkers is an effective non-surgical method for treating ESO. At the 6-month follow-up, the recurrence rate was 2.5% in Group A and 18.9% in Group B (p<0.05).

Maqola ma’lumotlari
MualliflarNАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-08-05
Jild11
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

экссудативный средний отит, дети, низкоинтенсивное лазерное излучение, аутоинсуффляция, топическая иммунокоррекция, трансферрин, церулоплазмин, sIgA, неинвазивный мониторинг, ОШ, 95% ДИ, exudative otitis media, children, low-intensity laser radiation, autoinsufflation, topical immunomodulation, transferrin, ceruloplasmin, sIgA, noninvasive monitoring, OS, 95% CI, ekssudativ o'rta otit, bolalar, past intensivlikli lazer, autoinsufflyatsiya, topik immunokorreksiya, transferrin, seruloplazmin, sIgA, noinvaziv monitoring, OR, 95% DI

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Tibbiyot

Iqtibos keltirish

APANАSRETDINOVА Maxzuna Taxsinovna, & DUSTBOBOEV Dilshod Sadullaevich (2026). OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14732
GOST (OAK)NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 3.
MLANАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich. “OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14732
ChicagoNАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich. “OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14732
HarvardNАSRETDINOVА Maxzuna Taxsinovna, and DUSTBOBOEV Dilshod Sadullaevich (2026) ‘OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(3). https://tadqiqot.uz/index.php/biomedicine/article/view/14732
BibTeX
@article{nsretdinovmaxzunataxsinovna2026,
  title = {OPTIMIZATION OF CONSERVATIVE TREATMENT FOR EXUDATIVE OTITIS MEDIA IN CHILDREN: THE SYNERGISTIC EFFECT OF PILN, TOPICAL IMMUNOCORRECTION, AND PLAY AUTOINSUFFLATION},
  author = {NАSRETDINOVА Maxzuna Taxsinovna and DUSTBOBOEV Dilshod Sadullaevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {3},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14732}
}

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