Objective: To conduct a comparative evaluation of the clinical and biochemical efficacy of an optimized three-component treatment regimen for the secretory phase of exudative otitis media (EOM) in children aged 1–5 years, comprising low-intensity laser therapy (LILT), topical immunocorrection, and playful autoinsufflation, compared with standard treatment. Methods: 172 children (ages 1–5 years) were examined: subgroup A (n=40) — LI + lysates + autoinsufflation; subgroup B (n=37) — standard treatment; comparison group (n=60); control group (n=35). Salivary biomarkers (transferrin, ceruloplasmin, sIgA, myeloperoxidase), tympanometry data, OEA, and CSVP were assessed every 5 days. Results: In group A, by day 14, the transferrin level decreased 3.2-fold (to 3.8 ± 0.5 mg/L), while sIgA increased 2.3-fold (to 0.28 ± 0.03 g/L; p < 0.001). By day 30, type A tympanogram was restored in 92.5% of children in group A (OR = 7.8; 95% CI 1.9–31.6; p < 0.05) and in 62.2% in group B. The need for adenotomy in Group A decreased by a factor of 4.9 (5% vs. 24.3%). During the 6-month follow-up, recurrence rates were 2.5% in Group A and 18.9% in Group B (p<0.05). Conclusion: The three-component regimen combined with non-invasive monitoring of biomarkers is an effective non-surgical method for treating ESO. At the 6-month follow-up, the recurrence rate was 2.5% in Group A and 18.9% in Group B (p<0.05).
| Mualliflar | NАSRETDINOVА Maxzuna Taxsinovna, DUSTBOBOEV Dilshod Sadullaevich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-08-05 |
| Jild | 11 |
| Son | 3 |
| Til | O‘zbek |
экссудативный средний отит, дети, низкоинтенсивное лазерное излучение, аутоинсуффляция, топическая иммунокоррекция, трансферрин, церулоплазмин, sIgA, неинвазивный мониторинг, ОШ, 95% ДИ, exudative otitis media, children, low-intensity laser radiation, autoinsufflation, topical immunomodulation, transferrin, ceruloplasmin, sIgA, noninvasive monitoring, OS, 95% CI, ekssudativ o'rta otit, bolalar, past intensivlikli lazer, autoinsufflyatsiya, topik immunokorreksiya, transferrin, seruloplazmin, sIgA, noinvaziv monitoring, OR, 95% DI
This study examined the diagnostic significance of transferrin and ceruloplasmin levels in oral fluid (OF) for diagnosing the secretory stage of exudative otitis media (EOM) in children aged 1–5 years. The study…
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