Efficacy of multimodal therapy in delaying precachexia progression in patients with reproductive organ cancers

MAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, RAKHIMOV Nodir Makhammatkulovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective: To evaluate the impact of combination therapy on inflammatory markers and metabolic parameters in stage IV ovarian, endometrial, and cervical cancer patients with precachexia. Materials and Methods: A prospective cohort study enrolled 55 women between 2023 and 2024. Eligible patients had confirmed precachexia according to Fearon criteria and ECOG performance status 1-2. The therapeutic regimen comprised celecoxib (400 mg/day), megestrol acetate (320-480 mg/day), omega-3 polyunsaturated fatty acids (2 g eicosapentaenoic acid/day), metformin (1500-2000 mg/day), and nutritional support. Follow-up duration was 24 weeks. Primary endpoints included C-reactive protein (CRP) dynamics, body weight stabilization, and appetite improvement assessed by FAACT scale. Secondary parameters encompassed interleukin-6, tumor necrosis factor-alpha, albumin levels, quality of life measured by EORTC QLQ-C30, and time to cachexia progression. Results: At week 4, median CRP decreased from 18.5 mg/L to 14.2 mg/L (23.2% reduction; p<0.001). Body weight stabilization occurred in 22 patients (40.0%) within 12 weeks. Appetite improvement was documented in 26 patients (47.3%). Interleukin-6 declined by 34.9% over 24 weeks (p<0.001), tumor necrosis factor-alpha by 21.8% (p<0.001). Albumin levels increased from 32.1 to 35.1 g/L (p<0.001). Global health status on EORTC QLQ-C30 improved from 42.3 to 53.8 points (p<0.001). Cachexia progression continued in 18 patients (32.7%). Grade 3-4 adverse events affected 12.7% of patients, predominantly gastrointestinal disorders. Conclusion: Multimodal therapy delays precachexia progression, reduces systemic inflammation markers, and enhances quality of life.vHowever, weight gain remains limited (20%), and cachexia progression persists in one-third of patients. Despite acceptable safety profile, more effective strategies are needed.

Maqola ma’lumotlari
MualliflarMAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, RAKHIMOV Nodir Makhammatkulovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-07-16
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

прекахексия, рак репродуктивных органов, мультимодальная терапия, маркеры воспаления, стабилизация массы тела, качество жизни, precachexia, reproductive organ cancer, multimodal therapy, inflammatory markers, weight stabilization, quality of life, prekaheksiya, reproduktiv organlar saratoni, multimodal terapiya, yallig'lanish markerlar, tana massasini barqarorlash, hayot sifati

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, & RAKHIMOV Nodir Makhammatkulovich (2026). EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14608
GOST (OAK)MAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, RAKHIMOV Nodir Makhammatkulovich EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLAMAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, and RAKHIMOV Nodir Makhammatkulovich. “EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14608
ChicagoMAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, and RAKHIMOV Nodir Makhammatkulovich. “EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14608
HarvardMAMEDOV Umid Sunnatovich, GAYSINA Elena Aleksandrovna, and RAKHIMOV Nodir Makhammatkulovich (2026) ‘EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14608
BibTeX
@article{mamedovumidsunnatovich2026,
  title = {EFFICACY OF MULTIMODAL THERAPY IN DELAYING PRECACHEXIA PROGRESSION IN PATIENTS WITH REPRODUCTIVE ORGAN CANCERS},
  author = {MAMEDOV Umid Sunnatovich and GAYSINA Elena Aleksandrovna and RAKHIMOV Nodir Makhammatkulovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14608}
}

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