The role of a differentiated approach in improving the effectiveness of minimally invasive drainage in tumor-induced biliary obstruction

KHUJABAEV Safarboy Tukhtabaevich, UROZOV Numon Sadullaevich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Obstructive jaundice caused by malignant tumors is a severe complication of hepatopancreatobiliary cancers. Its occurrence in advanced cases is frequent, and many patients eventually develop jaundice. Given that only 20–25% of these tumors are resectable, palliative biliary decompression methods are crucial. However, there is no single standard approach to malignant jaundice, and various minimally invasive techniques – endoscopic or percutaneous drainage, plastic or metal stenting, etc. – are employed based on institutional experience. This article presents a study of 149 patients with malignant obstructive jaundice who underwent 133 minimally invasive biliary drainages (either retrograde endoscopic or antegrade percutaneous) and 16 palliative surgical biliodigestive bypass operations. The outcomes were analyzed to develop a differentiated strategy for choosing the optimal drainage method depending on the tumor block level, anatomical considerations, expected patient survival, and performance status. The results demonstrate that minimally invasive biliary decompression effectively relieves jaundice in the majority of patients and is associated with fewer complications compared to open surgical bypass. Algorithms were developed suggesting that if expected survival is less than 6 months, biliary drainage with a plastic stent (via ERCP or PTC) is preferable, whereas for survival over 6 months, a self-expanding metal stent (SEMS) or surgical bypass should be considered. These findings indicate that a tailored approach can improve outcomes of malignant obstructive jaundice by reducing complication and mortality rates.

Maqola ma’lumotlari
MualliflarKHUJABAEV Safarboy Tukhtabaevich, UROZOV Numon Sadullaevich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-07-16
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

механическая желтуха; опухоли гепатопанкреатодуоденальной зоны; эндобилиарное стентирование; чрескожное дренирование; пластиковые стенты; саморасширяющиеся металлические стенты, obstructive jaundice; hepatopancreatobiliary tumors; endoscopic stenting; percutaneous drainage; plastic stents; self-expanding metal stents, mexanik sariqlik; gepatopankreatobiliar o‘sma; endoskopik stentlash; transhepatik drenaj

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKHUJABAEV Safarboy Tukhtabaevich, & UROZOV Numon Sadullaevich (2026). THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14609
GOST (OAK)KHUJABAEV Safarboy Tukhtabaevich, UROZOV Numon Sadullaevich THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLAKHUJABAEV Safarboy Tukhtabaevich, and UROZOV Numon Sadullaevich. “THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14609
ChicagoKHUJABAEV Safarboy Tukhtabaevich, and UROZOV Numon Sadullaevich. “THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14609
HarvardKHUJABAEV Safarboy Tukhtabaevich, and UROZOV Numon Sadullaevich (2026) ‘THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14609
BibTeX
@article{khujabaevsafarboytukhtabaevich2026,
  title = {THE ROLE OF A DIFFERENTIATED APPROACH IN IMPROVING THE EFFECTIVENESS OF MINIMALLY INVASIVE DRAINAGE IN TUMOR-INDUCED BILIARY OBSTRUCTION},
  author = {KHUJABAEV Safarboy Tukhtabaevich and UROZOV Numon Sadullaevich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14609}
}

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