Immunohistochemical characterization of reparative regeneration using hydrogel based on the sodium salt of carboxymethylcellullose in experimental antiglaucomatous surgery

BILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, SULTANOV Ozod Abdulla ugli

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Objective. To evaluate the antifibrotic efficacy of sodium carboxymethylcellulose (Na-CMC)-based hydrogel in experimental antiglaucomatous surgery using immunohistochemical (IHC) markers Ki-67 and desmin. Materials and Methods. The experiment was conducted on 36 rabbits (72 eyes) divided into three groups: control (no barrier material), comparative (Omnivisc viscoelastic), and experimental (Na-CMC hydrogel). Histological and IHC examinations were performed at designated time points following deep sinus trabeculoiridectomy. Expression levels of Ki-67 and desmin were used to assess cellular proliferation and myofibroblastic transformation. Results. In the control group, high expression levels of Ki-67 and desmin (up to 67%) indicated active fibrotic processes. The application of Na-CMC hydrogel significantly reduced the expression of both markers to near-physiological levels (Ki-67: 20.0±2.0%; desmin: 12.5±1.5%), suggesting effective suppression of inflammatory and fibrotic activity. Conclusion. Na-CMC hydrogel demonstrates a pronounced antifibrotic effect and may serve as a safe alternative to toxic antifibrotic agents in glaucoma surgery.

Maqola ma’lumotlari
MualliflarBILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, SULTANOV Ozod Abdulla ugli
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-07-16
Jild10
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

глаукома, послеоперационный фиброз, Na-КМЦ, иммуногистохимия, glaucoma, postoperative fibrosis, Na-CMC, immunohistochemistry, glaukoma, operatsiyadan keyingi fibroz, Na-KMS, immunogistokimyo

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Tibbiyot

Iqtibos keltirish

APABILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, & SULTANOV Ozod Abdulla ugli (2026). IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14613
GOST (OAK)BILALOV Bakhodir Erkinovich va b. IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 10, № 6.
MLABILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, and SULTANOV Ozod Abdulla ugli. “IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/14613
ChicagoBILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, and SULTANOV Ozod Abdulla ugli. “IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/14613
HarvardBILALOV Bakhodir Erkinovich, NISHANOV Daniyar Anarbaevich, BILALOV Erkin Nazimovich, ORIPOV Okilkhon Ilyasovich, and SULTANOV Ozod Abdulla ugli (2026) ‘IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(6). https://tadqiqot.uz/index.php/biomedicine/article/view/14613
BibTeX
@article{bilalovbakhodirerkinovich2026,
  title = {IMMUNOHISTOCHEMICAL CHARACTERIZATION OF REPARATIVE REGENERATION USING HYDROGEL BASED ON THE SODIUM SALT OF CARBOXYMETHYLCELLULLOSE IN EXPERIMENTAL ANTIGLAUCOMATOUS SURGERY},
  author = {BILALOV Bakhodir Erkinovich and NISHANOV Daniyar Anarbaevich and BILALOV Erkin Nazimovich and ORIPOV Okilkhon Ilyasovich and SULTANOV Ozod Abdulla ugli},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {10},
  number = {6},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/14613}
}

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