Objective: To develop and validate a diagnostic panel of biomarkers for early detection of precachexia in cancer patients. Materials and Methods: A prospective cohort study was conducted involving 197 patients, divided into three groups based on nutritional status: normal (n=64), precachexia (n=81), and cachexia (n=52). ROC analysis, internal consistency assessment (Cronbach's α), test-retest analysis, and correlation study methods were used. Biomarkers included C-reactive protein, interleukin-6, tumor necrosis factor-α, and albumin. Results: A statistically significant increase in inflammatory markers was found with the progression of nutritional deficiency. Interleukin-6 demonstrated the highest diagnostic value (area under the ROC curve 0.899). A combined model was developed with 91.1% sensitivity and 92.4% specificity, superior to individual biomarkers. Conclusions: A comprehensive approach to assessing inflammation and protein metabolism biomarkers significantly improves the accuracy of early precachexia diagnosis in cancer patients. The proposed diagnostic model can be recommended for clinical use to timely identify nutritional disorders.
Maqola ma’lumotlari
Mualliflar
Мамедов Умид Суннатович, Гайсина Елена Александровна, Рахимов Нодир Махамматкулович
Jurnal
Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали)
Муродова Малика Джамоловна, Юлдашев Ботир Ахматович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
Chronic kidney disease (CKD) is a serious public health problem due to the unpredictable course of the disease and complications arising from the lack of timely diagnosis and treatment. According to available data, the…
Закирова Нодира Исламовна, Абдуллаева Нигора Эркиновна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
Macrosomia is associated with perinatal and neonatal complications and is considered a significant problem in modern obstetrics. The postpartum period, especially in women who have given birth, is characterised by…
Наджимитдинов Ялкин Саидахматович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
The treatment results of 73 children aged 5 to 18 years were retrospectively evalu-ated. The average stone size was 10.0 ± 0.6 mm in length and 5.5 ± 0.7 mm in width. Complete stone removal was achieved in 71 patients…
Рахмонова Парвина Фаридуновна, Раббимова Гульнора Тоштемировна, Рафиков Санжар Шавкатович, Хамроева Лола Каххоровна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
Mayer–Rokitanskiy–Kustner–Hauser syndrome (MRKH) is a congenital anomaly characterized by the absence or underdevelopment of the uterus and upper part of the vagina, with a normal karyotype of 46XX and preserved ovarian…
Рафиков Санжар Шавкатович, Хамроева Лола Каххоровна, Негмаджанов Баходур Болтаевич, Ганиев Фахриддин Истамкулович, Саттаров Шариф Шавкатович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
Relevance: Congenital anomalies (malformations) of the female reproductive organs are persistent intrauterine deviations from normal variations in size, shape, proportions, symmetry, topography, and organogenesis…
Гаппарова Гули Нурмуминовна · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25
Юлдашев Санжар Келдиярович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-26
Pelvic organ prolapse (POP) is one of the most prevalent forms of pelvic floor dysfunction in women, particularly during the postmenopausal period. The relevance of this topic is underscored by the high prevalence of…
Акрамов Ахтам Рабимович · Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) · 2026-05-25