Objective: To develop and validate a diagnostic panel of biomarkers for early detection of precachexia in cancer patients. Materials and Methods: A prospective cohort study was conducted involving 197 patients, divided into three groups based on nutritional status: normal (n=64), precachexia (n=81), and cachexia (n=52). ROC analysis, internal consistency assessment (Cronbach's α), test-retest analysis, and correlation study methods were used. Biomarkers included C-reactive protein, interleukin-6, tumor necrosis factor-α, and albumin. Results: A statistically significant increase in inflammatory markers was found with the progression of nutritional deficiency. Interleukin-6 demonstrated the highest diagnostic value (area under the ROC curve 0.899). A combined model was developed with 91.1% sensitivity and 92.4% specificity, superior to individual biomarkers. Conclusions: A comprehensive approach to assessing inflammation and protein metabolism biomarkers significantly improves the accuracy of early precachexia diagnosis in cancer patients. The proposed diagnostic model can be recommended for clinical use to timely identify nutritional disorders.
| Mualliflar | Мамедов Умид Суннатович, Гайсина Елена Александровна, Рахимов Нодир Махамматкулович |
|---|---|
| Jurnal | Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали) |
| Nashriyot | Самарқанд давлат тиббиёт университети |
| ISSN | 2017-2021 |
| Nashr sanasi | 2026-05-26 |
| Jild | 6 |
| Son | 4 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
прекахексия, онкология, биомаркеры, интерлейкин-6, нутритивный статус, precachexia, oncology, biomarkers, interleukin-6, nutritional status, prekaxeksiya, onkologiya, biomarkerlar, interleykin-6, oziq-ovqat statusi
| APA | Мамедов Умид Суннатович, Гайсина Елена Александровна, & Рахимов Нодир Махамматкулович (2026). PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH. Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 6(4). https://tadqiqot.uz/index.php/uro/article/view/13945 |
|---|---|
| GOST (OAK) | Мамедов Умид Суннатович, Гайсина Елена Александровна, Рахимов Нодир Махамматкулович PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH // Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали). – 2026. – T. 6, № 4. |
| MLA | Мамедов Умид Суннатович, Гайсина Елена Александровна, and Рахимов Нодир Махамматкулович. “PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 6(4), 2026. https://tadqiqot.uz/index.php/uro/article/view/13945 |
| Chicago | Мамедов Умид Суннатович, Гайсина Елена Александровна, and Рахимов Нодир Махамматкулович. “PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH.” Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 6(4) (2026). https://tadqiqot.uz/index.php/uro/article/view/13945 |
| Harvard | Мамедов Умид Суннатович, Гайсина Елена Александровна, and Рахимов Нодир Махамматкулович (2026) ‘PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH’, Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали), 6(4). https://tadqiqot.uz/index.php/uro/article/view/13945 |
| BibTeX | @article{article2026,
title = {PRECACHEXIA BIOMARKERS IN WOMEN WITH REPRODUCTIVE SYSTEM CANCER: A COMPREHENSIVE DIAGNOSTIC APPROACH},
author = {Мамедов Умид Суннатович and Гайсина Елена Александровна and Рахимов Нодир Махамматкулович},
journal = {Journal of reproductive health and uro-nephrology research (Репродуктив саломатлик ва уро-нефрологик тадқиқотлар журнали)},
year = {2026},
volume = {6},
number = {4},
url = {https://tadqiqot.uz/index.php/uro/article/view/13945}
} |
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