This retrospective single‑center study (2020–2024) from the Pediatric Oncology Center in Tashkent evaluated the efficacy of incorporating blinatumomab (14‑day courses at 15 μg/m²/day, twice with a two‑month interval) into the ALL‑MB‑2015 protocol for children with B‑cell ALL who remained MRD‑positive post‑induction. All 25 patients achieved hematologic remission; MRD dropped from 12 % to 0.001 % after the first blinatumomab course, and remained negative after the second. Median follow‑up was 2.5 years. There were two late relapses (in standard‑ and intermediate‑risk groups), 4‑year EFS was 88.1 ± 3.7 %, and no deaths occurred. Adverse events (allergic reactions, neurotoxicity, hypoalbuminemia, cytopenias) were manageable.
| Mualliflar | IBRAGIMOVA Sapura, KLEVLEEVA Albina, BABAKHANOVA Nargiza, RIZAYEVA Feruza, ERIMBETOVA Indira, NIGMATOV Khamidhon, ARIPOVA Nazokat |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2025-11-21 |
| Jild | 10 |
| Son | 5 |
| Til | Ingliz |
острая лимфобластная лейкемия (ALL), блинатумомаб, минимальная остаточная болезнь (MRD), дети, протокол ALL MB 2015, ALL, blinatumomab, minimal residual disease, children, B-hujayrali OLL, blinatumomab, minimal qoldiq kasallik (MRD), bolalar, immunoterapiya
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