The study evaluated the effectiveness of combined treatment for differentiated thyroid cancer (DTC) considering morphological and molecular-genetic characteristics. A total of 300 patients treated at the Tashkent Branch of the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology (2014–2024) were included. The use of an improved algorithm (ultrasound, FNAB, molecular testing, and personalized surgery) resulted in higher two-year recurrence-free survival (78.1% vs. 66.5%; p=0.033). Unfavorable prognostic mutations included TERT, RAS, PAX8-PPAR-γ, and BRAF-V600E. Extended thyroidectomy with lymph node dissection reduced recurrence risk. Integration of molecular profiling improved survival and reduced treatment costs.
| Mualliflar | TILLYASHAYXOV Mirzagaleb Nigmatovich, MALIKOV Muzaffar Abduvaxobovich |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashriyot | Тошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ |
| ISSN | 2181-9300 |
| Nashr sanasi | 2025-11-25 |
| Jild | 10 |
| Son | 5 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-27 |
дифференцированный рак щитовидной железы, комбинированное лечение, молекулярно-генетический анализ, таргетная терапия, хирургия, прогноз, персонализированный подход, differentiated thyroid cancer, combined treatment, molecular-genetic analysis, targeted therapy, surgery, prognosis, personalized approach, differensiallashgan qalqonsimon bez saratoni, kombinasiyalashgan davolash, molekulyar-genetik tahlil, target terapiya, jarrohlik, prognoz, personallashtirilgan yondashuv
| APA | TILLYASHAYXOV Mirzagaleb Nigmatovich, & MALIKOV Muzaffar Abduvaxobovich (2025). EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12954 |
|---|---|
| GOST (OAK) | TILLYASHAYXOV Mirzagaleb Nigmatovich, MALIKOV Muzaffar Abduvaxobovich EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 5. |
| MLA | TILLYASHAYXOV Mirzagaleb Nigmatovich, and MALIKOV Muzaffar Abduvaxobovich. “EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12954 |
| Chicago | TILLYASHAYXOV Mirzagaleb Nigmatovich, and MALIKOV Muzaffar Abduvaxobovich. “EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12954 |
| Harvard | TILLYASHAYXOV Mirzagaleb Nigmatovich, and MALIKOV Muzaffar Abduvaxobovich (2025) ‘EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12954 |
| BibTeX | @article{tillyashayxovmirzagalebnigmatovich2025,
title = {EVALUATION OF THE EFFECTIVENESS OF COMBINED TREATMENT OF DIFFERENTIATED THYROID CANCER},
author = {TILLYASHAYXOV Mirzagaleb Nigmatovich and MALIKOV Muzaffar Abduvaxobovich},
journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
year = {2025},
volume = {10},
number = {5},
url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12954}
} |
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