Modern concepts of pathogenesis and morphological features of hpv-associated lesions of the vulva and cervix

SHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, KAMALOVA Barno Zafarovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

The article presents current data on the pathogenesis and morphological characteristics of HPV-associated lesions of the vulva and cervix. The mechanisms of viral DNA integration and expression of oncogenic proteins E6 and E7, leading to dysregulation of the cell cycle and neoplastic transformation of the epithelium, are discussed. Morphological features of intraepithelial neoplasia (CIN, VIN) and the diagnostic value of immunohistochemical markers p16, Ki-67, p53, and E-cadherin are described. The importance of differentiating HPV-dependent and HPV-independent carcinogenic pathways is emphasized. An integrated approach to early diagnosis and prevention of HPV-induced neoplasms of the lower female genital tract is presented.

Maqola ma’lumotlari
MualliflarSHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, KAMALOVA Barno Zafarovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-11-25
Jild10
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

ВПЧ-инфекция, шейка матки, вульва, неоплазия, p16, Ki-67, патогенез, морфология, HPV infection, cervix, vulva, neoplasia, p16, Ki-67, pathogenesis, morphology, ВПЧ инфекцияси, бачадон бўйни, вульва, неоплазия, p16, Ki-67, патогенез, морфология

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APASHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, & KAMALOVA Barno Zafarovna (2025). MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12955
GOST (OAK)SHAKHANOVA Shakhnoza Shavkatovna va b. MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 5.
MLASHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, and KAMALOVA Barno Zafarovna. “MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12955
ChicagoSHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, and KAMALOVA Barno Zafarovna. “MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12955
HarvardSHAKHANOVA Shakhnoza Shavkatovna, MADAMINOVA Sevarakhon Mukhammadjon kizi, ESANKULOVA Bustonoy Sobirovna, and KAMALOVA Barno Zafarovna (2025) ‘MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12955
BibTeX
@article{shakhanovashakhnozashavkatovna2025,
  title = {MODERN CONCEPTS OF PATHOGENESIS AND MORPHOLOGICAL FEATURES OF HPV-ASSOCIATED LESIONS OF THE VULVA AND CERVIX},
  author = {SHAKHANOVA Shakhnoza Shavkatovna and MADAMINOVA Sevarakhon Mukhammadjon kizi and ESANKULOVA Bustonoy Sobirovna and KAMALOVA Barno Zafarovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {5},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12955}
}

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