Specific features of organizing the anesthesiology service in an oncological clinic during major upper abdominal surgery

ISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Background. Major oncological surgeries involving the upper abdominal organs are associated with high surgical trauma, considerable risk of hemodynamic instability, and severe postoperative pain, which impose special requirements on the organization of anesthesiology services and the choice of multimodal techniques. Objective. To evaluate the clinical and organizational effects of a combined anesthetic approach (general anesthesia plus prolonged epidural block) compared with standard general anesthesia in patients undergoing major upper abdominal oncological surgery. Materials and Methods. A prospective comparative study was conducted at a national oncology hospital and a regional oncology clinic, including 200 patients. Group I: standard general anesthesia (n=103); Group II: general anesthesia combined with prolonged epidural block (n=97). Parameters assessed included hemodynamics, SpO₂, acid–base balance, intraoperative stress hormone levels (cortisol and catecholamines), postoperative pain intensity (VAS), need for opioid analgesics, as well as organizational indicators (quality of anesthetic records, resource utilization). Statistical analysis was performed using standard parametric and nonparametric methods, with significance set at p<0.05. Results. Compared with general anesthesia alone, the combined approach was associated with a lower incidence of intraoperative hypotension (17.5% vs. 34.0%) and arrhythmias (12.4% vs. 21.3%), fewer episodes of SpO₂ <92% (4.1% vs. 11.7%), reduced intraoperative stress hormone responses (mean cortisol increase +23% vs. +48%), and significantly lower postoperative pain scores (VAS day 1: 3.4±1.1 vs. 6.1±1.3). This was accompanied by decreased opioid consumption (14.4% vs. 39.8%) and improved quality of anesthetic documentation (errors 9.3% vs. 18.4%). Conclusions. The combination of general anesthesia with prolonged epidural block provides a more stable intraoperative course, attenuates the surgical stress response, and ensures superior postoperative analgesia, while simultaneously improving organizational aspects of anesthesiology practice. These findings are consistent with ERAS principles and support the implementation of standardized combined anesthesia protocols in oncological surgery.

Maqola ma’lumotlari
MualliflarISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-11-21
Jild10
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

анестезиологическая служба, онкохирургия, пролонгированная эпидуральная анестезия, ERAS, верхний этаж брюшной полости, anesthesiology service, oncological surgery, prolonged epidural anesthesia, ERAS, upper abdominal organs, anesteziologiya xizmati, onkologik jarrohlik, uzaytirilgan epidural anesteziya, ERAS, qorin bo‘shlig‘i yuqori qavati

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, & YUSUPOV Anvar Sobirovich (2025). SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12945
GOST (OAK)ISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 5.
MLAISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich. “SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/12945
ChicagoISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich. “SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/12945
HarvardISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich (2025) ‘SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/12945
BibTeX
@article{iskandarovashakhnozatulkinovna2025,
  title = {SPECIFIC FEATURES OF ORGANIZING THE ANESTHESIOLOGY SERVICE IN AN ONCOLOGICAL CLINIC DURING MAJOR UPPER ABDOMINAL SURGERY},
  author = {ISKANDAROVA Shakhnoza Tulkinovna and KHAKIMOVA Laylo Nuraliyevna and YUSUPOV Anvar Sobirovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {5},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/12945}
}

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