Study of the dynamics of prolactin and glucose levels in patients with gastric cancer during the perioperative period under combined epidural anesthesia

ISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Background. Data on the combined dynamics of prolactin and glucose in the perioperative period under combined epidural anesthesia in patients with gastric cancer remain limited. Objective. To assess changes in prolactin and glucose levels at stages T1–T3 under combined epidural anesthesia and determine their clinical significance. Materials and Methods. A single-center observational study included 39 patients (100%), with measurements performed at T1 (preoperative), T2 (intraoperative), and T3 (early postoperative period). Statistical indicators presented as M±m, Δ, Δ%, and CV. Results. Prolactin: 24.37±1.99 (T1) → 40.67±3.05 (T2; +66.9%) → 38.07±1.85 (T3; +56.2% vs. T1; –6.4% vs. T2); CV decreased from 50.99% to 30.35%. Glucose: 4.84±0.23 mmol/L (T1) → 4.65±0.17 (T2; –3.9%) → 4.66±0.18 (T3; –3.7% vs. T1); CV decreased from 29.68% to 24.12%. Glycemic values remained within physiological limits. Conclusion. Under combined epidural anesthesia, a profile is formed characterized by a “pronounced hormonal response with stable glycemia” and a reduction of interindividual variability; these findings confirm the controllability of the metabolic response in the early perioperative period.

Maqola ma’lumotlari
MualliflarISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-21
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

gastric cancer, combined epidural anesthesia, prolactin, glycemia, perioperative stress response., gastric cancer, combined epidural anesthesia, prolactin, glycemia, perioperative stress response., oshqozon saratoni, kombinatsiyalangan epidural anesteziya, prolaktin, glyukemiya, perioperatsion stress javobi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, & YUSUPOV Anvar Sobirovich (2026). STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13471
GOST (OAK)ISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, YUSUPOV Anvar Sobirovich STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich. “STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13471
ChicagoISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich. “STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13471
HarvardISKANDAROVA Shakhnoza Tulkinovna, KHAKIMOVA Laylo Nuraliyevna, and YUSUPOV Anvar Sobirovich (2026) ‘STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13471
BibTeX
@article{iskandarovashakhnozatulkinovna2026,
  title = {STUDY OF THE DYNAMICS OF PROLACTIN AND GLUCOSE LEVELS IN PATIENTS WITH GASTRIC CANCER DURING THE PERIOPERATIVE PERIOD UNDER COMBINED EPIDURAL ANESTHESIA},
  author = {ISKANDAROVA Shakhnoza Tulkinovna and KHAKIMOVA Laylo Nuraliyevna and YUSUPOV Anvar Sobirovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13471}
}

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