Human papillomavirus and oropharyngeal cancer: current clinical-epidemiological and prognostic aspects (review)

ABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, XASANOV Akbar Ibroximovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

In recent decades, oropharyngeal cancer has been characterized by a pronounced change in its epidemiological profile, mainly due to a significant increase in the proportion of human papillomavirus (HPV)–associated forms. Currently, HPV-positive oropharyngeal cancer is considered a distinct clinical and biological subtype of head and neck malignancies, differing from HPV-negative tumors in risk factors, morphological features, clinical behavior, and prognosis. This review summarizes current data on the prevalence of HPV-associated oropharyngeal cancer, the biology of the virus and the mechanisms of HPV-induced carcinogenesis, clinical and morphological characteristics, and modern diagnostic approaches. Special attention is paid to the prognostic significance of HPV status, the role of viral genotype, viral load, and the physical status of HPV in shaping clinical outcomes, as well as to contemporary concepts of personalized treatment and therapy de-escalation. It has been shown that integration of clinical, morphological, and molecular characteristics of HPV allows for more accurate prognostic stratification of patients and optimization of therapeutic strategies. The necessity of region-oriented studies to clarify the epidemiological and clinical-prognostic features of HPV-associated oropharyngeal cancer is emphasized.

Maqola ma’lumotlari
MualliflarABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, XASANOV Akbar Ibroximovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-21
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

рак ротоглотки; вирус папилломы человека; ВПЧ-ассоциированный рак; эпидемиология; канцерогенез; p16; диагностика; прогноз; персонализированное лечение, oropharyngeal cancer; human papillomavirus; HPV-associated cancer; epidemiology; carcinogenesis; p16; diagnosis; prognosis; personalized treatment, оғиз-халқум саратони; инсон папиллома вируси; ОПВ-ассоцияланган рак; эпидемиология; канцерогенез; p16; диагностика; прогноз; персоналлаштирилган даволаш

Ilmiy soha

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Iqtibos keltirish

APAABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, & XASANOV Akbar Ibroximovich (2026). HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW). Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13470
GOST (OAK)ABDIKARIMOV Azizbek Xurshidjon o`g`li va b. HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW) // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, and XASANOV Akbar Ibroximovich. “HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW).” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13470
ChicagoABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, and XASANOV Akbar Ibroximovich. “HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW).” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13470
HarvardABDIKARIMOV Azizbek Xurshidjon o`g`li, YUSUPBEKOV Abrorbek Akhmedjanovich, USMONOV Begzod Boymatovich, and XASANOV Akbar Ibroximovich (2026) ‘HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW)’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13470
BibTeX
@article{abdikarimovazizbekxurshidjonogli2026,
  title = {HUMAN PAPILLOMAVIRUS AND OROPHARYNGEAL CANCER: CURRENT CLINICAL-EPIDEMIOLOGICAL AND PROGNOSTIC ASPECTS (REVIEW)},
  author = {ABDIKARIMOV Azizbek Xurshidjon o`g`li and YUSUPBEKOV Abrorbek Akhmedjanovich and USMONOV Begzod Boymatovich and XASANOV Akbar Ibroximovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13470}
}

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