This article investigates the role of lymphocytic infiltration, assessed by the immunohistochemical marker CD45, in the pathogenesis of acute gastric mucosal injury in critically ill patients receiving mechanical ventilation in intensive care units. Increased CD45 expression was found to be associated with enhanced lymphocytic infiltration, activation of the local inflammatory response, impaired microcirculation, and progression of inflammatory and destructive changes in the gastric mucosa. The identified immunohistochemical alterations reflect the severity of the local immune response and may serve as an additional morphological criterion for assessing the severity of the pathological process. Quantitative assessment of CD45 expression using digital morphometric analysis provides an objective evaluation of inflammatory cell infiltration and contributes to a better understanding of the immunopathogenetic mechanisms underlying acute stress-induced gastric injury. The obtained findings may improve early morphological diagnosis, facilitate prediction of disease progression, and optimize preventive and therapeutic strategies for critically ill patients treated in intensive care units.
| Mualliflar | I.B. Dzhuraev, O.M. Kurbanov |
|---|---|
| Jurnal | Zamonaviy tibbiyot jurnali / Journal of modern medicine |
| Nashriyot | Андижон давлат тиббиёт институти |
| ISSN | 2992-8958 |
| Nashr sanasi | 2026-07-10 |
| Jild | 14 |
| Son | 3 |
| Betlar | 151-160 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| DOI | 10.67519/nshr.ztj.2026.03.032 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.67519/nshr.ztj.2026.03.032 · Maqolaning asl sahifasi · PDF
| APA | I.B. Dzhuraev, & O.M. Kurbanov (2026). THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 151-160. https://doi.org/10.67519/nshr.ztj.2026.03.032 |
|---|---|
| GOST (OAK) | I.B. Dzhuraev, O.M. Kurbanov THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 151-160. – DOI: 10.67519/nshr.ztj.2026.03.032. |
| MLA | I.B. Dzhuraev, and O.M. Kurbanov. “THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 151-160, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.032 |
| Chicago | I.B. Dzhuraev, and O.M. Kurbanov. “THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 151-160 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.032 |
| Harvard | I.B. Dzhuraev, and O.M. Kurbanov (2026) ‘THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 151-160. https://doi.org/10.67519/nshr.ztj.2026.03.032 |
| BibTeX | @article{ibdzhuraev2026,
title = {THE ROLE OF LYMPHOCYTIC INFILTRATION (CD45+) IN THE PATHOGENESIS OF ACUTE GASTRIC INJURY IN INTENSIVE CARE UNIT PATIENTS},
author = {I.B. Dzhuraev and O.M. Kurbanov},
journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
year = {2026},
volume = {14},
number = {3},
pages = {151-160},
doi = {10.67519/nshr.ztj.2026.03.032},
url = {https://doi.org/10.67519/nshr.ztj.2026.03.032}
} |
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