Factors associated with acute postoperative creatinine rise after open-heart surgery with cardiopulmonary bypass

M.M. Gofurjonov, Sh. Sh. Akhmadaliev

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication of open-heart surgery performed with cardiopulmonary bypass (CPB). The aim was to assess the frequency of, and factors associated with, a postoperative rise in serum creatinine defined by the absolute KDIGO criterion (increase ≥26.5 µmol/L) among patients in an institutional cardiac surgery registry managed with standard perioperative care. Data from 63 of 112 consecutive registry patients who underwent open-heart surgery with CPB and had paired pre- and postoperative creatinine values were analysed. The defined creatinine rise occurred in 10 of 63 patients (15.9%). Patients with a creatinine rise had a significantly lower baseline creatinine than those without (82 [78–97] vs 98 [88–110] µmol/L; p = 0.028), with a non-significant trend towards longer operative time (260 [250–300] vs 203 [176–255] min; p = 0.126). In multivariable analysis including baseline creatinine and operative duration, lower baseline creatinine remained independently associated with the outcome (adjusted odds ratio 0.92 per 1 µmol/L; 95% CI 0.85–0.99; p = 0.027); the model discriminated the outcome with an AUC of 0.786 (n = 59, 9 events). Given the small number of events and that the criterion captured an absolute rather than relative rise from differing baselines, this association likely partly reflects a statistical artefact (regression to the mean) rather than a protective effect of low creatinine, as confirmed by comparison with a larger prior institutional analysis (n = 300) in which higher baseline creatinine was associated with AKI. The findings are exploratory and highlight the limitations of retrospective registries with a single postoperative creatinine measurement for full KDIGO staging.

Maqola ma’lumotlari
MualliflarM.M. Gofurjonov, Sh. Sh. Akhmadaliev
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-28
Jild14
Son3
Betlar416-423
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.045
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.045 · Maqolaning asl sahifasi · PDF

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Iqtibos keltirish

APAM.M. Gofurjonov, & Sh. Sh. Akhmadaliev (2026). FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 416-423. https://doi.org/10.67519/nshr.ztj.2026.03.045
GOST (OAK)M.M. Gofurjonov, Sh. Sh. Akhmadaliev FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 416-423. – DOI: 10.67519/nshr.ztj.2026.03.045.
MLAM.M. Gofurjonov, and Sh. Sh. Akhmadaliev. “FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 416-423, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.045
ChicagoM.M. Gofurjonov, and Sh. Sh. Akhmadaliev. “FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 416-423 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.045
HarvardM.M. Gofurjonov, and Sh. Sh. Akhmadaliev (2026) ‘FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 416-423. https://doi.org/10.67519/nshr.ztj.2026.03.045
BibTeX
@article{mmgofurjonov2026,
  title = {FACTORS ASSOCIATED WITH ACUTE POSTOPERATIVE CREATININE RISE AFTER OPEN-HEART SURGERY WITH CARDIOPULMONARY BYPASS},
  author = {M.M. Gofurjonov and Sh. Sh. Akhmadaliev},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {416-423},
  doi = {10.67519/nshr.ztj.2026.03.045},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.045}
}

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