Molecular mechanisms and clinical efficacy of immunotherapy in cervical cancer: a systematic review from the perspective of neoadjuvant use in stage II disease

F.B. Jumanova

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

This article systematizes the molecular and biological mechanisms of tumor immune evasion in cervical cancer associated with high-risk human papillomavirus (HPV) infection and provides a comprehensive review of clinical evidence regarding the use of various classes of immunotherapeutic agents. Particular attention is paid to the rationale for their application in the neoadjuvant setting for stage II cervical cancer (T2a,b N0,1). The results of key clinical trials, including KEYNOTE-158, KEYNOTE-028, CheckMate 358, GOG 9929, and GOG 0265, are reviewed. The prognostic significance of PD-L1 expression, the density of tumor-infiltrating lymphocytes (TILs), and the synergistic effects of immunotherapy combined with radiotherapy are also analyzed. Summary tables of clinical outcomes and a schematic representation of immunopathological mechanisms are presented.

Maqola ma’lumotlari
MualliflarF.B. Jumanova
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-07
Jild14
Son3
Betlar59-65
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.047
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.047 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAF.B. Jumanova (2026). MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 59-65. https://doi.org/10.67519/nshr.ztj.2026.03.047
GOST (OAK)F.B. Jumanova MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 59-65. – DOI: 10.67519/nshr.ztj.2026.03.047.
MLAF.B. Jumanova. “MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 59-65, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.047
ChicagoF.B. Jumanova. “MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 59-65 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.047
HarvardF.B. Jumanova (2026) ‘MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 59-65. https://doi.org/10.67519/nshr.ztj.2026.03.047
BibTeX
@article{fbjumanova2026,
  title = {MOLECULAR MECHANISMS AND CLINICAL EFFICACY OF IMMUNOTHERAPY IN CERVICAL CANCER: A SYSTEMATIC REVIEW FROM THE PERSPECTIVE OF NEOADJUVANT USE IN STAGE II DISEASE},
  author = {F.B. Jumanova},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {59-65},
  doi = {10.67519/nshr.ztj.2026.03.047},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.047}
}

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