Association of the TCF7L2 RS12255372 variant with susceptibility to type 2 diabetes mellitus and early diabetic kidney disease

Z.A. Raximberdiyeva

Zamonaviy tibbiyot jurnali / Journal of modern medicine · 2026-yil

Annotatsiya

Background. Polymorphisms of the TCF7L2 gene are among the most important genetic risk factors for type 2 diabetes mellitus (T2DM); however, their role in the development of diabetic kidney disease (DKD) remains insufficiently understood. Objective. To evaluate the association between the TCF7L2 rs12255372 polymorphism and the risk of type 2 diabetes mellitus, as well as its relationship with renal function. Materials and Methods. The study included 86 patients with T2DM and 24 healthy controls. Genotyping of the TCF7L2 rs12255372 polymorphism was performed using polymerase chain reaction. Allele and genotype distributions were analyzed together with renal function parameters, including estimated glomerular filtration rate (eGFR), urea, creatinine, nephrin, and cystatin C. Results. The T allele was significantly more frequent in patients than in controls (29.7% vs. 2.1%; OR=19.8; 95% CI: 4.54–86.37; p=0.01). Carriers of the TT genotype demonstrated a significantly lower eGFR (74.8±3.24 mL/min/1.73 m²; p<0.01) and higher serum urea levels (7.90±1.28 mmol/L; p<0.05) compared with carriers of the GG and GT genotypes. Although differences in nephrin and cystatin C levels were not statistically significant, an increasing trend was observed among TT carriers. Conclusions. The TCF7L2 rs12255372 polymorphism, particularly the T allele, is associated with an increased risk of type 2 diabetes mellitus and early renal dysfunction. This genetic variant may serve as a promising molecular marker for early risk stratification of diabetic kidney disease.

Maqola ma’lumotlari
MualliflarZ.A. Raximberdiyeva
JurnalZamonaviy tibbiyot jurnali / Journal of modern medicine
NashriyotАндижон давлат тиббиёт институти
ISSN2992-8958
Nashr sanasi2026-07-10
Jild14
Son3
Betlar132-137
TilIngliz
Ilmiy sohaTibbiyot
DOI10.67519/nshr.ztj.2026.03.029
Indeksga qo‘shilgan2026-09-02

DOI: 10.67519/nshr.ztj.2026.03.029 · Maqolaning asl sahifasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAZ.A. Raximberdiyeva (2026). ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE. Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 132-137. https://doi.org/10.67519/nshr.ztj.2026.03.029
GOST (OAK)Z.A. Raximberdiyeva ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE // Zamonaviy tibbiyot jurnali / Journal of modern medicine. – 2026. – T. 14, № 3. – P. 132-137. – DOI: 10.67519/nshr.ztj.2026.03.029.
MLAZ.A. Raximberdiyeva. “ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 132-137, 2026. https://doi.org/10.67519/nshr.ztj.2026.03.029
ChicagoZ.A. Raximberdiyeva. “ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE.” Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 132-137 (2026). https://doi.org/10.67519/nshr.ztj.2026.03.029
HarvardZ.A. Raximberdiyeva (2026) ‘ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE’, Zamonaviy tibbiyot jurnali / Journal of modern medicine, 14(3), 132-137. https://doi.org/10.67519/nshr.ztj.2026.03.029
BibTeX
@article{zaraximberdiyeva2026,
  title = {ASSOCIATION OF THE TCF7L2 RS12255372 VARIANT WITH SUSCEPTIBILITY TO TYPE 2 DIABETES MELLITUS AND EARLY DIABETIC KIDNEY DISEASE},
  author = {Z.A. Raximberdiyeva},
  journal = {Zamonaviy tibbiyot jurnali / Journal of modern medicine},
  year = {2026},
  volume = {14},
  number = {3},
  pages = {132-137},
  doi = {10.67519/nshr.ztj.2026.03.029},
  url = {https://doi.org/10.67519/nshr.ztj.2026.03.029}
}

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