This study aimed to evaluate the diagnostic significance of the cytokines IL-6, TNF-α, and IL-10 for the early prediction of severe COVID-19. The study included 98 patients with severe COVID-19 and 40 healthy individuals in the control group. Cytokine concentrations were determined using enzyme-linked immunosorbent assay (ELISA), and their predictive value was assessed by receiver operating characteristic (ROC) analysis. The results demonstrated that the area under the ROC curve (AUC) was 0.922 for IL-6, 0.852 for TNF-α, and 0.905 for IL-10. All biomarkers investigated showed high sensitivity and specificity and were statistically significant (p < 0.001). The findings indicate that IL-6, TNF-α, and IL-10 are important biomarkers for the early prediction of severe COVID-19. Their combined assessment may facilitate the timely identification of high-risk patients and contribute to optimizing clinical management and treatment strategies.
| Mualliflar | Меҳринисо Ризоевна Мирзоева, Уктам Холов |
|---|---|
| Jurnal | Ўзбекистон метрологияси |
| Nashriyot | Ўзбекистон техник жиҳатдан тартибга солиш агентлиги |
| ISSN | 2181-3663 |
| Nashr sanasi | 2026-06-05 |
| Jild | 5 |
| Son | 3 |
| Betlar | 777-785 |
| Til | O‘zbek |
| Ilmiy soha | Texnika |
| DOI | 10.47689/2181-3663-vol5-iss3-pp777-785 |
| Indeksga qo‘shilgan | 2026-09-02 |
DOI: 10.47689/2181-3663-vol5-iss3-pp777-785 · Maqolaning asl sahifasi · PDF
| APA | Меҳринисо Ризоевна Мирзоева, & Уктам Холов (2026). COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти. Ўзбекистон метрологияси, 5(3), 777-785. https://doi.org/10.47689/2181-3663-vol5-iss3-pp777-785 |
|---|---|
| GOST (OAK) | Меҳринисо Ризоевна Мирзоева, Уктам Холов COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти // Ўзбекистон метрологияси. – 2026. – T. 5, № 3. – B. 777-785. – DOI: 10.47689/2181-3663-vol5-iss3-pp777-785. |
| MLA | Меҳринисо Ризоевна Мирзоева, and Уктам Холов. “COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти.” Ўзбекистон метрологияси, 5(3), 777-785, 2026. https://doi.org/10.47689/2181-3663-vol5-iss3-pp777-785 |
| Chicago | Меҳринисо Ризоевна Мирзоева, and Уктам Холов. “COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти.” Ўзбекистон метрологияси, 5(3), 777-785 (2026). https://doi.org/10.47689/2181-3663-vol5-iss3-pp777-785 |
| Harvard | Меҳринисо Ризоевна Мирзоева, and Уктам Холов (2026) ‘COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти’, Ўзбекистон метрологияси, 5(3), 777-785. https://doi.org/10.47689/2181-3663-vol5-iss3-pp777-785 |
| BibTeX | @article{article2026,
title = {COVID-19 инфекцияси оғир кечишини башорат қилишда IL-6, TNF-α ва IL-10 цитокинларининг диагностик аҳамияти},
author = {Меҳринисо Ризоевна Мирзоева and Уктам Холов},
journal = {Ўзбекистон метрологияси},
year = {2026},
volume = {5},
number = {3},
pages = {777-785},
doi = {10.47689/2181-3663-vol5-iss3-pp777-785},
url = {https://doi.org/10.47689/2181-3663-vol5-iss3-pp777-785}
} |
Boshqa maqola uchun iqtibos tayyorlash
This article presents a comparative assessment of laboratory and biochemical markers of cytolysis, cholestasis, and hepatic synthetic function in patients with liver cirrhosis of various etiologies. Furthermore, it…
This study is devoted to the investigation of the clinical, laboratory, and prognostic features of cytopenic syndromes in patients with anemic conditions in the Republic of Karakalpakstan. The clinical manifestations…
This study evaluated the association between CYP2E1 c2 allele carriage and the clinical and laboratory severity of alcohol-related liver cirrhosis. Sixty patients were divided into a c1/c1 genotype group (n=39) and a…
Metabolic syndrome (MS) is a complex of interrelated metabolic disorders, including abdominal obesity, insulin resistance, arterial hypertension, dyslipidemia, and disorders of carbohydrate metabolism. The prevalence of…
This article evaluates the distribution of alleles and genotypes of the IL6 rs1800795 (−174 G>C) polymorphism and their predictive significance in the development of post-measles complications. The G allele and G/G…
The authors analyzed 20-year changes, regional characteristics depending on social factors, frequency, hygienic features, and the prevalence of EB among patients identified in the population of three regions of the…
This study evaluated the association between carriage of the CYP2E1 c2 allele, nutritional risk, and quality of life in patients with alcohol-related liver cirrhosis. The analysis included 60 patients: 39 with the c1/c1…
The aim of this study was to assess the clinical significance of cystatin C levels in patients with coronary artery disease after coronary stenting and to determine their value in predicting adverse cardiovascular…
Objective. To evaluate the prognostic significance of individual blood coagulation factors—fibrinogen A, platelet count, thrombotest grade, and prothrombin index—for rebleeding in patients with acute gastroduodenal…
The article reviews current evidence on the efficacy and safety of bevacizumab in the treatment of recurrent laryngeal papillomatosis. It summarizes the outcomes of systemic and intralesional therapy, including their…
Ўзбекистон метрологияси — barcha maqolalar · 2026-yil arxivi
This article evaluates the distribution of alleles and genotypes of the IL6 rs1800795 (−174 G>C) polymorphism and their predictive significance in the development of post-measles complications. The G allele and G/G…
The COVID-19 pandemic has impacted the lives of millions of people worldwide. Although its impact on the upper respiratory tract and lungs has been widely studied, the exact clinical and diagnostic features of airway…
This article examines compression as a meaning-oriented strategy in sign language translation and interpreting. Compression is understood not as arbitrary shortening, but as the selective reformulation of a source…
This study investigates the impact of Edge Computing on bandwidth utilization in Internet of Things (IoT)–driven Nigerian telecom networks. The rapid growth of IoT devices has significantly increased data traffic…
This article analyzes the scientific, pedagogical, and methodological foundations for the effective integration of national upbringing factors with modern global competencies in the context of continuous education…
This article addresses the problem of improving an adaptive traffic signal control algorithm at urban intersections by taking into account the dynamic characteristics of traffic flow. Fixed-time control under conditions…
Maqolada paxta xomashyosini yirik iflosliklardan tozalash jarayonida arrali baraban va kolosnikli panjara o‘rtasidagi o‘zaro ta’sirni takomillashtirish masalasi ko‘rib chiqilgan. Mavjud tozalagichlarda qo‘llaniladigan…
Maqolada paxta xomashyosini yirik va mayda iflosliklardan tozalash samaradorligini oshirishga qaratilgan ilmiy tadqiqotlar tizimlashtirilib, konstruktiv va texnologik omillarning o‘zaro ta’siri qiyosiy tahlil qilindi…