Relevance. The primary strategy for glaucoma treatment is the reduction of intraocular pressure (IOP) using topical ocular hypotensive medications; however, many patients require multiple drugs to achieve adequate IOP control. Purpose. To evaluate the efficacy and safety of a fixed combination of brinzolamide 1%/brimonidine 0.2% (FCBB) compared to the simultaneous administration of a non-fixed combination of brinzolamide 1% and brimonidine 0.2% in patients with primary open-angle glaucoma (POAG). Materials and methods. The study included 60 patients (120 eyes) with POAG, divided into two groups. The main group (n=30) received FCBB twice daily, while the comparison group (n=30) received a non-fixed combination of brinzolamide 1% and brimonidine 0.2% with a ≥10-minute interval between instillations. Efficacy was assessed by the dynamics of intraocular pressure (IOP) reduction on day 1, day 7, and at 1, 3, and 6 months of therapy. Tolerability and the incidence of adverse events were also evaluated. Results. Both treatment regimens resulted in a significant IOP reduction. In the FCBB group, IOP decreased by 26% at 8:00 and 31% at 10:00 on day 1. After 6 months, the reduction was 35% at 8:00 and 40% at 10:00, which was comparable to or slightly better than the results of the non-fixed combination group (32–39%). The incidence of adverse events was low in both groups. Conclusion. FCBB demonstrated highhypotensive efficacy and a favorable safety profile, providing stable IOP reduction with minimal side effects.
| Mualliflar | Baxritdinova F.A., Narzikulova K.I., Egamberdiyeva M.E. |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2025-12-26 |
| Jild | 15 |
| Son | 4 |
| Betlar | 17-22 |
| DOI | 10.57231/j.ao.2025.15.4.003 |
DOI: 10.57231/j.ao.2025.15.4.003 · Maqolaning asl sahifasi · PDF
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