Relevance. Diabetic retinopathy (DR) is one of the late complications of DM. An important role in the pathogenesis of its appearance is played by endothelial growth factor. Purpose. Evaluate the effectiveness of SMPLE and its combination with anti-VEGF therapy in the treatment of diabetic macular edema (DME) against the background of non-proliferative diabetic retinopathy. Materials and methods. In total, the study included 42 patients (67 eyes) with DME who were randomized into 2 groups. Group I (18 patients, 29 eyes) — anti-VEGF therapy in the 1+PRN mode (once + «as needed»). Group II (24 patients, 38 eyes) combined treatment was carried out: SMPLE + anti-VEGF therapy (once + «as needed»). Results. In patients receiving combination therapy, the frequency of additional injections was significantly lower: 67.5% of patients did not need further administration of anti-VEGF drug after the loading phase compared with 11.1% in the monoanti-VEGF therapy group. Conclusion. SMPLE at a wavelength of 577 nm is safe for the structures of the chorioretinal complex, since it does not have a destructive effect on the cells of the retinal pigment epithelium.
| Mualliflar | Н.Р. Янгиева, А. О. Гиясова |
|---|---|
| Jurnal | Передовая Офтальмология |
| Nashr sanasi | 2023-02-22 |
| Jild | 1 |
| Son | 1 |
| Betlar | 199-202 |
| Til | ru |
| DOI | 10.57231/j.ao.2023.1.1.047 |
DOI: 10.57231/j.ao.2023.1.1.047 · Maqolaning asl sahifasi · PDF
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