The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major

Mozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, Mohaddeseh Behjati

PULSE · 2020-yil

Annotatsiya

Background: Iron accumulation leads to increased susceptibility to cardiovascular diseases in thalassemia major (TM) patients. Depressed heart rate variability (HRV) and development of arrhythmia are among the manifestations of subclinical cardiac involvement in TM cases. Determination of subclinical cardiac involvement is essential for preventive measures. Thus, we aimed to evaluate the best method for identification of subclinical cardiac dysfunction in TM cases. Materials and Methods: In this prospective study, 45 TM and 45 non-TM cases, who were referred for cardiac evaluation, were enrolled. Exclusion criteria included non-sinus rhythm and overt cardiac disease. TM cases underwent cardiac MRI, electrocardiography (ECG), and Holter monitoring. TM cases were divided into two groups of normal versus iron overload with a cardiac T2* of more or less than 20 ms, respectively. The non-TM cases underwent only ECG and Holter monitoring. Results: We observed no significant difference regarding HRV between normal versus iron overload TM and non-TM cases. Higher rates of premature atrial complex, low limb voltage, low atrial rhythm, as well as minimum and average HR with lower QRS duration and PR interval were detected in TM versus non-TM cases (p value <0.05). Conclusions: We observed a higher prevalence of low limb voltage and low atrial rhythm in TM cases versus non-TM cases. Indeed, the role of fragmented QRS (fQRS) for subclinical detection of cardiac disease in TM cases is still so controversial and needs more evaluation. Application of HRV and fQRS in this regard may need to be performed at the right time point after initiation of blood transfusion, but this needs to be determined.

Maqola ma’lumotlari
MualliflarMozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, Mohaddeseh Behjati
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2020-01-01
Jild8
Son1-2
Betlar15-20
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000505556
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000505556 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAMozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, & Mohaddeseh Behjati (2020). The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major. PULSE, 8(1-2), 15-20. https://doi.org/10.1159/000505556
GOST (OAK)Mozhgan Parsaee va b. The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major // PULSE. – 2020. – T. 8, № 1-2. – P. 15-20. – DOI: 10.1159/000505556.
MLAMozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, and Mohaddeseh Behjati. “The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major.” PULSE, 8(1-2), 15-20, 2020. https://doi.org/10.1159/000505556
ChicagoMozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, and Mohaddeseh Behjati. “The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major.” PULSE, 8(1-2), 15-20 (2020). https://doi.org/10.1159/000505556
HarvardMozhgan Parsaee, Amir Farjam Fazelifar, Elham Ansaripour, Azita Azarkeyvan, Behshid Ghadrdoost, Ashraf Charmizadeh, and Mohaddeseh Behjati (2020) ‘The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major’, PULSE, 8(1-2), 15-20. https://doi.org/10.1159/000505556
BibTeX
@article{mozhganparsaee2020,
  title = {The Role of Heart Rate Variability and Fragmented QRS for Determination of Subclinical Cardiac Involvement in Beta-Thalassemia Major},
  author = {Mozhgan Parsaee and Amir Farjam Fazelifar and Elham Ansaripour and Azita Azarkeyvan and Behshid Ghadrdoost and Ashraf Charmizadeh and Mohaddeseh Behjati},
  journal = {PULSE},
  year = {2020},
  volume = {8},
  number = {1-2},
  pages = {15-20},
  doi = {10.1159/000505556},
  url = {https://doi.org/10.1159/000505556}
}

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