The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits

Toshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, Kohji Shirai

PULSE · 2024-yil

Annotatsiya

Introduction: Acute hemorrhage decreases blood pressure (BP) and sometimes causes hypovolemic shock. At this time, peripheral arteries are supposed to contract and increase peripheral vascular resistance to raise BP. However, there has not been an adequate index of a degree of arterial stiffness. We assessed changes in arterial stiffness during rapid bleeding using new BP-independent vascular indices, aBeta and ifBeta, determined by applying the cardio-ankle vascular index theory to the elastic (aorta) and muscular (common iliac-femoral) arteries, respectively, in rabbits. Methods: Eleven Japanese white male rabbits were fixed at the supine position under pentobarbital anesthesia. Fifteen percent of the total blood volume was depleted at a rate of 2 mL/kg/min for 6 min; 15 min later, the withdrawn blood was re-transfused at the same rate. Pressure waves at the origin of the aorta (oA), distal end of the abdominal aorta (dA), distal end of the left common iliac artery (fA), and flow waves at oA were measured simultaneously. Beta was calculated using the following formula: beta = 2ρ/PP × ln(SBP/DBP) × PWV2, where ρ, SBP, DBP, and PP are blood density, systolic, diastolic, and pulse pressures, respectively. aBeta, ifBeta, and aortic-iliac-femoral beta (aifBeta) were calculated using aPWV, ifPWV, and aifPWV, respectively. Results: BP declined significantly at oA, dA, and fA during the acute bleeding. aBeta and aifBeta increased significantly from 3.7 and 5.0 before the bleeding (control) to 5.0 (about 34%) and 6.3 (about 26%) on average, while ifBeta decreased significantly from 20.5 before the bleeding to 17.1 (about 17%) after the completion of the bleeding. Reverse reactions of those indices were observed by transfusing the removed blood. Conclusion: Total arterial stiffness (aifBeta) increased; however, the elastic and muscular arteries stiffened and softened during the bleeding, respectively. These results would give useful diagnostic information during fall in BP.

Maqola ma’lumotlari
MualliflarToshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, Kohji Shirai
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2024-01-01
Jild12
Son1
Betlar76-84
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000539480
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000539480 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAToshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, & Kohji Shirai (2024). The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits. PULSE, 12(1), 76-84. https://doi.org/10.1159/000539480
GOST (OAK)Toshiro Ito va b. The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits // PULSE. – 2024. – T. 12, № 1. – P. 76-84. – DOI: 10.1159/000539480.
MLAToshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, and Kohji Shirai. “The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits.” PULSE, 12(1), 76-84, 2024. https://doi.org/10.1159/000539480
ChicagoToshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, and Kohji Shirai. “The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits.” PULSE, 12(1), 76-84 (2024). https://doi.org/10.1159/000539480
HarvardToshiro Ito, Shin-ichiro Katsuda, Yuko Horikoshi, T Funyu, Akihiro Hazama, Tsuyoshi Shimizu, and Kohji Shirai (2024) ‘The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits’, PULSE, 12(1), 76-84. https://doi.org/10.1159/000539480
BibTeX
@article{toshiroito2024,
  title = {The Responses of Arterial Stiffness Parameter Beta-Derived Index of the Aorta and Illiac-Femoral Artery to Acute Hypovolemia in Rabbits},
  author = {Toshiro Ito and Shin-ichiro Katsuda and Yuko Horikoshi and T Funyu and Akihiro Hazama and Tsuyoshi Shimizu and Kohji Shirai},
  journal = {PULSE},
  year = {2024},
  volume = {12},
  number = {1},
  pages = {76-84},
  doi = {10.1159/000539480},
  url = {https://doi.org/10.1159/000539480}
}

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