Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review

Sonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, Antonio Genovese

PULSE · 2024-yil

Annotatsiya

Background: /μL on two different examinations within a month of each other and/or a 20% or higher percentage of eosinophils in a bone marrow section, associated with organ damage. Rarely, neurological manifestations may occur, even in the early stages. We report a case of idiopathic hypereosinophilic syndrome with Loeffler endocarditis presenting with multiple bilateral strokes and encephalopathy as the first clinical manifestations. Summary: Hypereosinophilia and echocardiographic findings suggested a Loeffler's endocarditis. Blood hyperviscosity and small vessels inflammation induced by the hypereosinophilia itself, the embolization of intracardiac thrombus, along with the impaired clearance of microthrombi in the watershed areas, are the main mechanisms involved in the pathophysiology of stroke in the hypereosinophilic syndrome. Additionally, encephalopathy could be considered as a consequence of multiple cerebral infarcts and neurotoxicity induced by hypereosinophilia since our patient's confusion and aggressive behavior gradually remitted after steroid therapy was started. Key Messages: To the best of our knowledge, our case report is a rare instance highlighting neurological involvement as the earliest manifestation of hypereosinophilia. We aimed to elucidate the central nervous system involvement in this intriguing disorder, with the goal of encouraging clinicians to consider hypereosinophilic syndrome in the diagnostic assessment of rare stroke etiologies.

Maqola ma’lumotlari
MualliflarSonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, Antonio Genovese
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2024-01-01
Jild12
Son1
Betlar106-112
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000539379
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000539379 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APASonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, & Antonio Genovese (2024). Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review. PULSE, 12(1), 106-112. https://doi.org/10.1159/000539379
GOST (OAK)Sonia Romano va b. Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review // PULSE. – 2024. – T. 12, № 1. – P. 106-112. – DOI: 10.1159/000539379.
MLASonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, and Antonio Genovese. “Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review.” PULSE, 12(1), 106-112, 2024. https://doi.org/10.1159/000539379
ChicagoSonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, and Antonio Genovese. “Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review.” PULSE, 12(1), 106-112 (2024). https://doi.org/10.1159/000539379
HarvardSonia Romano, Giulia Avola, Marco Cesare Angeli, Francesca Brazzale, Elena Giacopazzi, Paola Castellini, and Antonio Genovese (2024) ‘Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review’, PULSE, 12(1), 106-112. https://doi.org/10.1159/000539379
BibTeX
@article{soniaromano2024,
  title = {Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review},
  author = {Sonia Romano and Giulia Avola and Marco Cesare Angeli and Francesca Brazzale and Elena Giacopazzi and Paola Castellini and Antonio Genovese},
  journal = {PULSE},
  year = {2024},
  volume = {12},
  number = {1},
  pages = {106-112},
  doi = {10.1159/000539379},
  url = {https://doi.org/10.1159/000539379}
}

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