Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease

Ichiro Wakabayashi, Yoko Sotoda

PULSE · 2025-yil

Annotatsiya

Introduction: Cardio-ankle vascular index (CAVI), a blood pressure-independent measure of heart-ankle pulse wave velocity, is a relatively new indicator of arterial stiffness. The absolute value of the difference in right CAVI and left CAVI (diff-CAVI) has been proposed as a new indicator of leg ischemia in patients with lower extremity arterial disease (LEAD). The aim of this study was to elucidate the relationships between diff-CAVI and peptides related to hypertensive disorders of pregnancy (HDP), which have been proposed as biomarkers for leg ischemia in patients with LEAD. Methods: The participants were 165 outpatients with LEAD who had already received medication therapy for LEAD. The relationships between diff-CAVI and serum levels of the seven HDP-related peptides, which were measured by mass spectrometry, were investigated. Results: HDP-related peptides with m/z 2091 (P-2091) and m/z 2378 (P-2378) showed significant positive correlations with diff-CAVI, and odds ratios (ORs) for large diff-CAVI (≥1.05) of the 3rd vs. 1st tertile groups of P-2091 (OR [99.3% confidence interval]: 3.71 [1.24–11.15]) and P-2378 (OR: 4.46 [1.39–14.30]) were significantly higher (p < 0.01) than the reference level. The associations of P-2091 and P-2378 with diff-CAVI were shown to be independent of age, gender, habit of smoking, history of diabetes, BMI, and blood pressure in multivariate analyses. The other peptides with m/z 2081, 2127, 2209, 2858, and 3156 did not show significant associations with diff-CAVI. Conclusion: P-2091 and P-2378 were associated with diff-CAVI and are thought to be useful indicators of leg ischemia in patients with LEAD.

Maqola ma’lumotlari
MualliflarIchiro Wakabayashi, Yoko Sotoda
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2025-02-03
Jild13
Son1
Betlar80-91
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000543726
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000543726 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAIchiro Wakabayashi, & Yoko Sotoda (2025). Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease. PULSE, 13(1), 80-91. https://doi.org/10.1159/000543726
GOST (OAK)Ichiro Wakabayashi, Yoko Sotoda Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease // PULSE. – 2025. – T. 13, № 1. – P. 80-91. – DOI: 10.1159/000543726.
MLAIchiro Wakabayashi, and Yoko Sotoda. “Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease.” PULSE, 13(1), 80-91, 2025. https://doi.org/10.1159/000543726
ChicagoIchiro Wakabayashi, and Yoko Sotoda. “Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease.” PULSE, 13(1), 80-91 (2025). https://doi.org/10.1159/000543726
HarvardIchiro Wakabayashi, and Yoko Sotoda (2025) ‘Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease’, PULSE, 13(1), 80-91. https://doi.org/10.1159/000543726
BibTeX
@article{ichirowakabayashi2025,
  title = {Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in Patients with Lower Extremity Arterial Disease},
  author = {Ichiro Wakabayashi and Yoko Sotoda},
  journal = {PULSE},
  year = {2025},
  volume = {13},
  number = {1},
  pages = {80-91},
  doi = {10.1159/000543726},
  url = {https://doi.org/10.1159/000543726}
}

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