The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry)

Yumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario

PULSE · 2025-yil

Annotatsiya

Introduction: Chronic kidney disease (CKD) raises cardiovascular risk, but its link with the cardio-ankle vascular index (CAVI) in diabetic and non-diabetic patients remains unclear. The aim of this study was to clarify the relationships between CAVI values and an aspect of renal function. Methods: We investigated the relationships among CAVI values, proteinuria, and the estimated glomerular filtration rate (eGFR) in 4,682 patients enrolled in a multicenter prospective coupling study (patients aged ≥30 years with at least one cardiovascular risk factor) and both eGFR and proteinuria data available. Based on vascular insufficiency guidelines, we classified the patients as having low (<8) or high (≥8) CAVI values. Results: The proteinuria positivity rate differed significantly between the low- and high-CAVI groups, and the difference was significant even after adjusting for age, gender, and other factors. Although direct comparisons showed a higher proportion of CKD (eGFR <60 mL/min/1.73 m2) in the high-CAVI group, this difference disappeared after adjustment. We further divided the low- and high-CAVI groups into diabetes mellitus (DM) and no diabetes mellitus (non-DM) subgroups to examine the rate of proteinuria positivity and the percentage of patients with eGFRs <60 mL/min/1.73 m2. After the multivariate analysis adjustment, the odds ratios for positive proteinuria the high-CAVI group were 1.69 (confidence interval [CI]: 1.08–2.63, p = 0.021) for the non-DM subgroup and 0.91 (95% CI: 0.56–1.47, p = 0.705) for the DM subgroup. The percentage of patients with eGFRs <60 mL/min/1.73 m2 was not significantly different between the low- and high-CAVI groups in both the DM and non-DM subgroups after the multivariate analysis adjustment (p = 0.088 for non-DM and p = 0.135 for DM). Conclusions: Proteinuria was associated with a CAVI ≥8 in patients without DM. High arterial stiffness may serve as a surrogate marker for renal damage in non-diabetic patients.

Maqola ma’lumotlari
MualliflarYumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2025-12-22
Jild14
Son1
Betlar12-19
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000550196
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000550196 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAYumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, & Kazuomi Kario (2025). The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry). PULSE, 14(1), 12-19. https://doi.org/10.1159/000550196
GOST (OAK)Yumiko Fujita va b. The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry) // PULSE. – 2025. – T. 14, № 1. – P. 12-19. – DOI: 10.1159/000550196.
MLAYumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, and Kazuomi Kario. “The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry).” PULSE, 14(1), 12-19, 2025. https://doi.org/10.1159/000550196
ChicagoYumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, and Kazuomi Kario. “The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry).” PULSE, 14(1), 12-19 (2025). https://doi.org/10.1159/000550196
HarvardYumiko Fujita, Tomoyuki Kabutoya, Satoshi Hoshide, and Kazuomi Kario (2025) ‘The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry)’, PULSE, 14(1), 12-19. https://doi.org/10.1159/000550196
BibTeX
@article{yumikofujita2025,
  title = {The Relationships among the Cardio-Ankle Vascular Index Values, Proteinuria, and Estimated Glomerular Filtration Rate in Diabetic and Non-Diabetic Patients (the Coupling Registry)},
  author = {Yumiko Fujita and Tomoyuki Kabutoya and Satoshi Hoshide and Kazuomi Kario},
  journal = {PULSE},
  year = {2025},
  volume = {14},
  number = {1},
  pages = {12-19},
  doi = {10.1159/000550196},
  url = {https://doi.org/10.1159/000550196}
}

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