Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms

Xinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, Junli Zuo

PULSE · 2025-yil

Annotatsiya

Introduction: The pulse wave analysis technology in the specialist SphygmoCor XCEL device has now been implemented in the CONNEQT Pulse device, which is a conventional sphygmomanometer suitable for home blood pressure (BP) monitoring. The aim of this study was to compare the correlation and consistency of measurements between the two devices. Methods: The study was conducted in participants admitted to the Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. Brachial BP (bBP), central BP (cBP), augmentation pressure (AP), augmentation index (AIx), and subendocardial viability ratio (SEVR) were measured with the CONNEQT Pulse and the SphygmoCor XCEL devices, both using a calibrated cuff-based brachial waveform. Results: A total of 367 eligible subjects, aged 23–92 (57.6 ± 13.0) years, of whom 254 (69.2%) were male, was enrolled in this study. Paired t tests showed relatively low bias and elevated standard deviation: cSBP mm Hg ([121.7 ± 17.2] vs. [117.5 ± 14.5], p < 0.001), cDBP ([80.6 ± 11.0] vs. [78.3 ± 11.4], p < 0.001), cPP ([41.0 ± 12.7] vs. [39.2 ± 9.5], p < 0.001), AP mm Hg ([11.5 ± 6.2] vs. [12.8 ± 6.6], p < 0.001), AI ([26.4 ± 9.0]% vs. [31.9 ± 14.0]%, p < 0.01), and SEVR ([135.6 ± 25.5]% vs. [137.8 ± 26.4]%, p = 0.02). cDBP (r = 0.812) measured by both devices was strongly correlated, cSBP (r = 0.762), cPP (r = 0.702) and SEVR (r = 0.778) were strongly correlated, whereas AP (r = 0.587) and AIx (r = 0.522) were moderately correlated (all p < 0.001). For intraclass correlation coefficient (ICC) for both devices, cDBP (ICC = 0.794) and SEVR (ICC = 0.776) showed good reproducibility, while cSBP (ICC = 0.727), cPP (ICC = 0.666), AIx (ICC = 0.428), and AP (ICC = 0.575) showed good to modest reproducibility. The differences between cSBP, cDBP, cPP, AP, AIx, and SEVR measured by the two devices were 4.2 ± 11.2 mm Hg, 2.3 ± 6.9 mm Hg, −1.8 ± 9.0 mm Hg, −1.3 ± 5.8 mm Hg, −5.6 ± 12.0%, and 2.1 ± 17.3%, respectively. Conclusion: Both devices show strong cBP-bBP correlations and low bias, suggesting that the new CONNEQT Pulse provides similar measurements of cBP to the original SphygmoCor XCEL. Although there is greater variability in waveform parameters, the magnitude of differences is within acceptable limits for meaningful use in conventional home BP monitoring. The relatively elevated variability in measurement precision (standard deviation), most likely due to sequential measurements with both devices in the same arm, needs to be further evaluated using simultaneous measurements in both arms.

Maqola ma’lumotlari
MualliflarXinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, Junli Zuo
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2025-10-07
Jild13
Son1
Betlar157-165
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000548849
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000548849 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAXinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, & Junli Zuo (2025). Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms. PULSE, 13(1), 157-165. https://doi.org/10.1159/000548849
GOST (OAK)Xinyue Zhou va b. Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms // PULSE. – 2025. – T. 13, № 1. – P. 157-165. – DOI: 10.1159/000548849.
MLAXinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, and Junli Zuo. “Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms.” PULSE, 13(1), 157-165, 2025. https://doi.org/10.1159/000548849
ChicagoXinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, and Junli Zuo. “Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms.” PULSE, 13(1), 157-165 (2025). https://doi.org/10.1159/000548849
HarvardXinyue Zhou, Xibao Shi, Yueliang Hu, Biwen Tang, Yakun Li, Mark Butlin, Alberto Avolio, and Junli Zuo (2025) ‘Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms’, PULSE, 13(1), 157-165. https://doi.org/10.1159/000548849
BibTeX
@article{xinyuezhou2025,
  title = {Comparison of Non-Invasive Estimation of Central Aortic Blood Pressure and Biomarkers of Vascular Health Measured by Two Devices Using Brachial Cuff Waveforms},
  author = {Xinyue Zhou and Xibao Shi and Yueliang Hu and Biwen Tang and Yakun Li and Mark Butlin and Alberto Avolio and Junli Zuo},
  journal = {PULSE},
  year = {2025},
  volume = {13},
  number = {1},
  pages = {157-165},
  doi = {10.1159/000548849},
  url = {https://doi.org/10.1159/000548849}
}

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