Course of epileptic seizures in patients after traumatic brain injury: clinical observations of 23 cases

Aliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, Aliev Mansur Abdukholikovich

Research Focus · 2025-yil

Annotatsiya

Post-traumatic epilepsy (PTE) is one of the most disabling long-term complications of traumatic brain injury (TBI). Despite progress in acute neurotrauma care, epileptic seizures remain a major cause of morbidity, drug resistance, and impaired quality of life among survivors. Objective: To analyze the course, clinical features, and outcomes of epileptic seizures in patients with TBI. Methods: A total of 23 patients with post-traumatic seizures were observed for a mean follow-up of 24 months. Clinical data, electroencephalography (EEG), and neuroimaging findings were assessed. Seizures were classified according to the International League Against Epilepsy (ILAE 2017). Treatment outcomes and the rate of drug-resistant epilepsy (DRE) were evaluated. Results: Early post-traumatic seizures occurred in 30.4% of patients, while late seizures predominated (69.6%). Generalized tonic–clonic seizures were the most frequent type (51.2%). EEG abnormalities were present in 78.3% of cases, most often localized to the temporal lobes. Cortical contusions and hematomas were the leading imaging correlates. Levetiracetam was the most commonly prescribed antiepileptic drug (60.8%). Seizure control was achieved in 65.2% of patients, whereas 34.8% developed DRE. Psychiatric comorbidities (depression and anxiety) were reported in 26.1%. Conclusion: Epileptic seizures after TBI are predominantly late in onset and frequently associated with temporal lobe lesions. Approximately one-third of patients develop drug resistance, underscoring the need for early risk stratification, individualized therapy, and preventive strategies to reduce the burden of PTE.

Maqola ma’lumotlari
MualliflarAliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, Aliev Mansur Abdukholikovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2025-12-05
Jild4
Son11
Betlar226-235
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i11.1860
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v4i11.1860 · Maqolaning asl sahifasi

Kalit so‘zlar

traumatic brain injury, post-traumatic epilepsy, epileptic seizures, EEG, neuroimaging, drug-resistant epilepsy, quality of life, черепно-мозговая травма, посттравматическая эпилепсия, эпилептические приступы, ЭЭГ, нейровизуализация, фармакорезистентная эпилепсия, качество жизни, bosh miya jarohati, posttravmatik epilepsiya, epileptik xurujlar, EEG, neyrovizualizatsiya, dorilarga chidamli epilepsiya, hayot sifati

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAAliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, & Aliev Mansur Abdukholikovich (2025). COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES. Research Focus, 4(11), 226-235. https://doi.org/10.66073/researchfocus.v4i11.1860
GOST (OAK)Aliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, Aliev Mansur Abdukholikovich COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES // Research Focus. – 2025. – T. 4, № 11. – P. 226-235. – DOI: 10.66073/researchfocus.v4i11.1860.
MLAAliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, and Aliev Mansur Abdukholikovich. “COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES.” Research Focus, 4(11), 226-235, 2025. https://doi.org/10.66073/researchfocus.v4i11.1860
ChicagoAliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, and Aliev Mansur Abdukholikovich. “COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES.” Research Focus, 4(11), 226-235 (2025). https://doi.org/10.66073/researchfocus.v4i11.1860
HarvardAliev Mansur Abdukholikovich, Алиев Мансур Абдухоликович, and Aliev Mansur Abdukholikovich (2025) ‘COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES’, Research Focus, 4(11), 226-235. https://doi.org/10.66073/researchfocus.v4i11.1860
BibTeX
@article{alievmansurabdukholikovich2025,
  title = {COURSE OF EPILEPTIC SEIZURES IN PATIENTS AFTER TRAUMATIC BRAIN INJURY: CLINICAL OBSERVATIONS OF 23 CASES},
  author = {Aliev Mansur Abdukholikovich and Алиев Мансур Абдухоликович and Aliev Mansur Abdukholikovich},
  journal = {Research Focus},
  year = {2025},
  volume = {4},
  number = {11},
  pages = {226-235},
  doi = {10.66073/researchfocus.v4i11.1860},
  url = {https://doi.org/10.66073/researchfocus.v4i11.1860}
}

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