Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment

ALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, OZTURK, Sait

Research Focus · 2026-yil

Annotatsiya

Background. Deep brain stimulation (DBS) is an established functional stereotactic neurosurgical treatment for selected patients with Parkinson disease (PD) who have disabling tremor, rigidity, bradykinesia, motor fluctuations, or insufficient symptom control despite pharmacotherapy. We report a male patient born in 1969 with symptom onset in 2016 and a tremor-rigid PD phenotype classified as Hoehn–Yahr stage IV. Case Report. At admission, the predominant manifestations included persistent upper-limb tremor, hypokinesia, muscular rigidity, hypomimia, freezing of gait, propulsion, retropulsion, lateropulsion, postural instability with falls, lower-limb weakness, and autonomic dysfunction. Despite ongoing antiparkinsonian therapy, the symptoms progressed. On August 28, 2025, bilateral frame-based DBS was performed using a Zamorano–Duchovny stereotactic system (Inomed, Germany), stereotactic multislice CT, Medtronic DICOM-based navigation, and intraoperative C-arm verification. According to the operative record, the electrodes were implanted into the posterior ventrolateral thalamic region. The implantable pulse generator was positioned in the right upper chest. Conclusion. This case illustrates the value of individualized stereotactic planning in advanced tremor-rigid PD and the importance of separately quantifying tremor suppression, rigidity, bradykinesia, gait, balance, and functional independence. Missing standardized scale and programming values in this working manuscript are explicitly marked as simulated and must be replaced with actual patient measurements before scientific submission.

Maqola ma’lumotlari
MualliflarALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, OZTURK, Sait
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-10-05
Jild5
Son9
Betlar43-51
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/refocus.v5i9.0904
Indeksga qo‘shilgan2026-10-18

DOI: 10.66073/refocus.v5i9.0904 · Maqolaning asl sahifasi

Kalit so‘zlar

Parkinson disease, deep brain stimulation, DBS, thalamus, tremor, rigidity, stereotactic neurosurgery, neuromodulation, MDS-UPDRS, neurorehabilitation, Parkinson kasalligi, DBS, miyaning chuqur stimulyatsiyasi, talamus, tremor, rigidlik, stereotaksiya, neyromodulyatsiya, MDS-UPDRS, neyroreabilitatsiya, болезнь Паркинсона, глубокая стимуляция мозга, DBS, таламус, тремор, ригидность, стереотаксия, нейромодуляция, MDS-UPDRS, нейрореабилитация

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, & OZTURK, Sait (2026). Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment. Research Focus, 5(9), 43-51. https://doi.org/10.66073/refocus.v5i9.0904
GOST (OAK)ALIEV, Mansur Abdukholikovich va b. Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment // Research Focus. – 2026. – T. 5, № 9. – P. 43-51. – DOI: 10.66073/refocus.v5i9.0904.
MLAALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait. “Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment.” Research Focus, 5(9), 43-51, 2026. https://doi.org/10.66073/refocus.v5i9.0904
ChicagoALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait. “Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment.” Research Focus, 5(9), 43-51 (2026). https://doi.org/10.66073/refocus.v5i9.0904
HarvardALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait (2026) ‘Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment’, Research Focus, 5(9), 43-51. https://doi.org/10.66073/refocus.v5i9.0904
BibTeX
@article{alievmansurabdukholikovich2026,
  title = {Bilateral deep brain stimulation of the posterior ventrolateral thalamic region in stage IV tremor-rigid Parkinson disease: a case report with multimodal assessment},
  author = {ALIEV, Mansur Abdukholikovich and OZTURK, Sait and АЛИЕВ, Мансур Абдухоликович and ОЗТЮРК, Саит and ALIYEV, Mansur Abduxoliqovich and OZTURK, Sait},
  journal = {Research Focus},
  year = {2026},
  volume = {5},
  number = {9},
  pages = {43-51},
  doi = {10.66073/refocus.v5i9.0904},
  url = {https://doi.org/10.66073/refocus.v5i9.0904}
}

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