Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report

ALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, OZTURK, Sait

Research Focus · 2026-yil

Annotatsiya

Background. Deep brain stimulation (DBS) is an established functional neurosurgical treatment for carefully selected patients with advanced Parkinson disease (PD). Clinical outcome depends on target selection, electrode localization, stimulation parameters, phenotype, and the severity of axial manifestations. Case Report. We describe a 44-year-old man with an approximately 17-year history of tremor-rigid PD with a prominent postural-kinetic component. His neurological phenotype included severe limb tremor, hypokinesia, muscular rigidity, hypomimia, freezing of gait, propulsion, retropulsion, lateropulsion, impaired balance, and recurrent falls. Disease severity corresponded to Hoehn–Yahr stage IV, with a Karnofsky Performance Status of 70. On August 28, 2025, bilateral frame-based DBS of the posterior ventrolateral thalamic region was performed using a Zamorano–Duchovny stereotactic system, MSCT-based registration, Medtronic DBS navigation, and intraoperative C-arm verification. The intracranial leads were connected to a subcutaneous implantable pulse generator placed in the right upper chest. Postoperative management included individualized stimulation programming, pharmacological adjustment, gait and balance rehabilitation, and longitudinal assessment using MDS-UPDRS, PDQ-39, MoCA, Berg Balance Scale, Timed Up and Go, and the Freezing of Gait Questionnaire. Conclusion. Bilateral motor thalamic DBS may provide substantial tremor suppression in advanced tremor-rigid PD. In patients with prominent axial dysfunction, however, optimal outcome requires a multimodal strategy integrating stereotactic accuracy, individualized programming, medication adjustment, and structured neurorehabilitation.

Maqola ma’lumotlari
MualliflarALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, OZTURK, Sait
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-10-05
Jild5
Son9
Betlar52-61
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/refocus.v5i9.0905
Indeksga qo‘shilgan2026-10-18

DOI: 10.66073/refocus.v5i9.0905 · Maqolaning asl sahifasi

Kalit so‘zlar

Parkinson disease, deep brain stimulation, DBS, motor thalamus, ventrolateral thalamus, tremor, rigidity, freezing of gait, stereotactic neurosurgery, neurorehabilitation, Parkinson kasalligi, DBS, miyaning chuqur stimulyatsiyasi, talamus, tremor, rigidlik, yurish muzlashi, stereotaksiya, neyroreabilitatsiya, болезнь Паркинсона, глубокая стимуляция мозга, DBS, таламус, вентролатеральное ядро, тремор, ригидность, freezing of gait, стереотаксия, нейрореабилитация

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, & OZTURK, Sait (2026). Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report. Research Focus, 5(9), 52-61. https://doi.org/10.66073/refocus.v5i9.0905
GOST (OAK)ALIEV, Mansur Abdukholikovich va b. Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report // Research Focus. – 2026. – T. 5, № 9. – P. 52-61. – DOI: 10.66073/refocus.v5i9.0905.
MLAALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait. “Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report.” Research Focus, 5(9), 52-61, 2026. https://doi.org/10.66073/refocus.v5i9.0905
ChicagoALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait. “Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report.” Research Focus, 5(9), 52-61 (2026). https://doi.org/10.66073/refocus.v5i9.0905
HarvardALIEV, Mansur Abdukholikovich, OZTURK, Sait, АЛИЕВ, Мансур Абдухоликович, ОЗТЮРК, Саит, ALIYEV, Mansur Abduxoliqovich, and OZTURK, Sait (2026) ‘Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report’, Research Focus, 5(9), 52-61. https://doi.org/10.66073/refocus.v5i9.0905
BibTeX
@article{alievmansurabdukholikovich2026,
  title = {Bilateral posterior ventrolateral thalamic deep brain stimulation in stage IV tremor-rigid Parkinson disease with prominent axial dysfunction: a case report},
  author = {ALIEV, Mansur Abdukholikovich and OZTURK, Sait and АЛИЕВ, Мансур Абдухоликович and ОЗТЮРК, Саит and ALIYEV, Mansur Abduxoliqovich and OZTURK, Sait},
  journal = {Research Focus},
  year = {2026},
  volume = {5},
  number = {9},
  pages = {52-61},
  doi = {10.66073/refocus.v5i9.0905},
  url = {https://doi.org/10.66073/refocus.v5i9.0905}
}

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