Outcomes of surgical treatment of drug resistant epilepsy

Abduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, Abduvoyitov Bobur Bahodirovich

Research Focus · 2025-yil

Annotatsiya

Background. Pharmacoresistant epilepsy (PRE) remains one of the most challenging neurological conditions, often unresponsive to pharmacological therapy. Surgical intervention is considered the most effective treatment option for selected patients. Objective. This article summarizes current approaches and outcomes of surgical treatment for PRE, highlighting prognostic factors, surgical techniques, neuropsychological outcomes, and quality of life (QoL) considerations. Methods. A review of contemporary literature was conducted, analyzing prospective and retrospective studies, meta-analyses, and clinical trials evaluating outcomes after anterior temporal lobectomy with amygdalohippocampectomy (ATL+AH), selective amygdalohippocampectomy (SAH), and minimally invasive techniques, including MRI-guided laser interstitial thermal therapy (MgLiTT), stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RFTC), and neuromodulation procedures (vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation). Favorable surgical outcomes are strongly associated with concordant neuroimaging and EEG findings, as well as the extent of resection of the epileptogenic zone. ATL+AH remains the gold standard, demonstrating seizure freedom in up to 70–80% of patients, while SAH offers comparable seizure control with improved preservation of neurocognitive functions. Minimally invasive techniques and neuromodulation provide alternative options for patients with multifocal or surgically inaccessible lesions. Neuropsychological assessments indicate that surgery can halt cognitive decline associated with ongoing seizures and improve QoL, although risks of postoperative deficits remain, particularly with left-sided resections. Multiple studies confirm significant postoperative improvement in QoL scores (QOLIE-31), especially in seizure-free patients. Conclusion. Surgical treatment of PRE is superior to long-term pharmacotherapy in carefully selected patients, providing seizure freedom, stabilization of cognitive functions, and improved QoL. Early identification of pharmacoresistance and timely surgical referral are crucial for optimizing long-term outcomes.

Maqola ma’lumotlari
MualliflarAbduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, Abduvoyitov Bobur Bahodirovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2025-12-05
Jild4
Son11
Betlar207-213
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v4i11.1858
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v4i11.1858 · Maqolaning asl sahifasi

Kalit so‘zlar

фармакорезистентная эпилепсия, хирургия эпилепсии, передняя височная лобэктомия, селективная амигдалогиппокампэктомия, лазерная интерстициальная термотерапия, нейростимуляция, когнитивные исходы, farmakorezistent epilepsiya, epilepsiya jarrohligi, oldingi chakka lobektomiyasi, selektiv amigdalo-gippokampektomiya, lazer interstitsial termoterapiya, neyrostimulyatsiya, kognitiv natijalar, hayot sifati, Pharmacoresistant epilepsy, Epilepsy surgery, Anterior temporal lobectomy, Selective amygdalohippocampectomy, Laser interstitial thermal therapy, Neuromodulation, Cognitive outcomes, Quality of life

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAAbduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, & Abduvoyitov Bobur Bahodirovich (2025). OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY. Research Focus, 4(11), 207-213. https://doi.org/10.66073/researchfocus.v4i11.1858
GOST (OAK)Abduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, Abduvoyitov Bobur Bahodirovich OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY // Research Focus. – 2025. – T. 4, № 11. – P. 207-213. – DOI: 10.66073/researchfocus.v4i11.1858.
MLAAbduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, and Abduvoyitov Bobur Bahodirovich. “OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY.” Research Focus, 4(11), 207-213, 2025. https://doi.org/10.66073/researchfocus.v4i11.1858
ChicagoAbduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, and Abduvoyitov Bobur Bahodirovich. “OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY.” Research Focus, 4(11), 207-213 (2025). https://doi.org/10.66073/researchfocus.v4i11.1858
HarvardAbduvoyitov Bobur Bahodirovich, Абдувоитов Бобур Баходирович, and Abduvoyitov Bobur Bahodirovich (2025) ‘OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY’, Research Focus, 4(11), 207-213. https://doi.org/10.66073/researchfocus.v4i11.1858
BibTeX
@article{abduvoyitovboburbahodirovich2025,
  title = {OUTCOMES OF SURGICAL TREATMENT OF DRUG RESISTANT EPILEPSY},
  author = {Abduvoyitov Bobur Bahodirovich and Абдувоитов Бобур Баходирович and Abduvoyitov Bobur Bahodirovich},
  journal = {Research Focus},
  year = {2025},
  volume = {4},
  number = {11},
  pages = {207-213},
  doi = {10.66073/researchfocus.v4i11.1858},
  url = {https://doi.org/10.66073/researchfocus.v4i11.1858}
}

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