Structural causes of drug-resistant epilepsy and their relationship with the clinical semiology of epileptic seizures

Abduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, Abduvoyitov, Bobur Bahodirovich

Research Focus · 2026-yil

Annotatsiya

Drug-resistant epilepsy is one of the most complex problems in modern clinical neurology, epileptology, and functional neurosurgery. Structural forms of the disease are of particular importance, as epileptic seizures in these cases are associated with a morphologically identifiable brain lesion. A retrospective clinical and neuroimaging study was conducted and included 120 patients with structural drug-resistant epilepsy. All patients underwent clinical and anamnestic assessment, neurological examination, electroencephalography, and brain magnetic resonance imaging. The most common structural causes were mesial temporal sclerosis, focal cortical dysplasia, benign epilepsy-associated tumors, post-traumatic gliosis, cavernous malformations, and post-stroke lesions. Mesial temporal sclerosis was found to be more frequently associated with focal impaired-awareness seizures and temporal auras, focal cortical dysplasia with early disease onset and seizure polymorphism, and post-traumatic and post-stroke lesions with more pronounced focal neurological deficits. The findings emphasize the need for comprehensive assessment of the structural substrate, clinical semiology, and functional status of the patient when planning diagnostic and therapeutic strategies.

Maqola ma’lumotlari
MualliflarAbduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, Abduvoyitov, Bobur Bahodirovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-07-05
Jild5
Son6
Betlar244-255
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v5i6.2412
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v5i6.2412 · Maqolaning asl sahifasi

Kalit so‘zlar

drug-resistant epilepsy, structural epilepsy, mesial temporal sclerosis, focal cortical dysplasia, cavernous malformation, post-traumatic gliosis, post-stroke epilepsy, clinical semiology, magnetic resonance imaging, epileptogenic zone, farmakorezistent epilepsiya, struktur epilepsiya, mezial temporal skleroz, fokal kortikal displaziya, kavernoz malformatsiya, posttravmatik glioz, postinsult epilepsiya, klinik semiologiya, magnit-rezonans tomografiya, epileptogen zona, фармакорезистентная эпилепсия, структурная эпилепсия, мезиальный темпоральный склероз, фокальная кортикальная дисплазия, кавернозная мальформация, посттравматический глиоз, постинсультная эпилепсия, клиническая семиология, магнитно-резонансная томография, эпилептогенная зона

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAAbduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, & Abduvoyitov, Bobur Bahodirovich (2026). STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES. Research Focus, 5(6), 244-255. https://doi.org/10.66073/researchfocus.v5i6.2412
GOST (OAK)Abduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, Abduvoyitov, Bobur Bahodirovich STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES // Research Focus. – 2026. – T. 5, № 6. – P. 244-255. – DOI: 10.66073/researchfocus.v5i6.2412.
MLAAbduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, and Abduvoyitov, Bobur Bahodirovich. “STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES.” Research Focus, 5(6), 244-255, 2026. https://doi.org/10.66073/researchfocus.v5i6.2412
ChicagoAbduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, and Abduvoyitov, Bobur Bahodirovich. “STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES.” Research Focus, 5(6), 244-255 (2026). https://doi.org/10.66073/researchfocus.v5i6.2412
HarvardAbduvoyitov, Bobur Bakhodirovich, Абдувойитов, Бобур Баходирович, and Abduvoyitov, Bobur Bahodirovich (2026) ‘STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES’, Research Focus, 5(6), 244-255. https://doi.org/10.66073/researchfocus.v5i6.2412
BibTeX
@article{abduvoyitovboburbakhodirovich2026,
  title = {STRUCTURAL CAUSES OF DRUG-RESISTANT EPILEPSY AND THEIR RELATIONSHIP WITH THE CLINICAL SEMIOLOGY OF EPILEPTIC SEIZURES},
  author = {Abduvoyitov, Bobur Bakhodirovich and Абдувойитов, Бобур Баходирович and Abduvoyitov, Bobur Bahodirovich},
  journal = {Research Focus},
  year = {2026},
  volume = {5},
  number = {6},
  pages = {244-255},
  doi = {10.66073/researchfocus.v5i6.2412},
  url = {https://doi.org/10.66073/researchfocus.v5i6.2412}
}

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