Optimized multicomponent drug therapy with colchicine in the prevention of angina recurrence in patients after percutaneous coronary intervention

Agababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, Kurbonov, Bekzod Xolmuminovich

Research Focus · 2026-yil

Annotatsiya

Despite successful percutaneous coronary intervention (PCI), recurrent angina remains a significant clinical problem. This prospective randomized controlled study included 120 patients who had undergone successful PCI. The patients were randomized into two groups of 60 people each. The main group received standard therapy in combination with colchicine at a dose of 0.5 mg/day, while the control group received only standard therapy. The follow-up period was 12 months. The primary endpoint was the frequency of recurrent angina. Secondary endpoints included achievement of target LDL-C levels, changes in inflammatory markers (hs-CRP, IL-6), quality of life (SF-36 and HADS questionnaires), and the frequency of major adverse cardiovascular events (MACE). After 12 months, recurrent angina occurred in 7 (11.7%) patients in the main group compared with 17 (28.3%) patients in the control group (p = 0.006; OR = 0.41; 95% CI 0.19–0.89). The main group showed a statistically more pronounced decrease in hs-CRP (−38.4% vs −12.7%, p < 0.001), a higher rate of achieving the target LDL-C level < 1.4 mmol/L (68.3% vs 41.7%, p < 0.01), and greater improvement in the physical component of health according to the SF-36 scale (+18.4 vs +9.7 points, p < 0.01). The MACE rate was lower in the main group (8.3% vs 18.3%, p = 0.047). Colchicine was well tolerated. The addition of low-dose colchicine to standard therapy significantly reduces recurrent angina, suppresses residual inflammation, and improves long-term prognosis in patients after PCI.

Maqola ma’lumotlari
MualliflarAgababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, Kurbonov, Bekzod Xolmuminovich
JurnalResearch Focus
NashriyotВетеринария ИТИ ва “Илм-фан ва инновациялар академияси” МЧЖ
ISSN2181-3833
Nashr sanasi2026-07-05
Jild5
Son6
Betlar269-275
TilIngliz
Ilmiy sohaVeterinariya
DOI10.66073/researchfocus.v5i6.2414
Indeksga qo‘shilgan2026-09-08

DOI: 10.66073/researchfocus.v5i6.2414 · Maqolaning asl sahifasi

Kalit so‘zlar

ischemic heart disease, percutaneous coronary intervention, recurrent angina, colchicine, secondary prevention, inflammation, personalized therapy, ishemik yurak kasalligi, teri orqali koronar aralashuv, qaytalanuvchi stenokardiya, kolxitsin, ikkilamchi profilaktika, yallig‘lanish, personallashtirilgan terapiya, ишемическая болезнь сердца, чрескожное коронарное вмешательство, рецидивирующая стенокардия, колхицин, вторичная профилактика, воспаление, персонифицированная терапия

Ilmiy soha

Veterinariya

Iqtibos keltirish

APAAgababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, & Kurbonov, Bekzod Xolmuminovich (2026). OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION. Research Focus, 5(6), 269-275. https://doi.org/10.66073/researchfocus.v5i6.2414
GOST (OAK)Agababyan, Irina Rubenovna va b. OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION // Research Focus. – 2026. – T. 5, № 6. – P. 269-275. – DOI: 10.66073/researchfocus.v5i6.2414.
MLAAgababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, and Kurbonov, Bekzod Xolmuminovich. “OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION.” Research Focus, 5(6), 269-275, 2026. https://doi.org/10.66073/researchfocus.v5i6.2414
ChicagoAgababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, and Kurbonov, Bekzod Xolmuminovich. “OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION.” Research Focus, 5(6), 269-275 (2026). https://doi.org/10.66073/researchfocus.v5i6.2414
HarvardAgababyan, Irina Rubenovna, Kurbanov, Bekzod Kholmuminovich, Агабабян, Ирина Рубеновна, Курбанов, Бекзод Холмуминович, Agababyan, Irina Rubenovna, and Kurbonov, Bekzod Xolmuminovich (2026) ‘OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION’, Research Focus, 5(6), 269-275. https://doi.org/10.66073/researchfocus.v5i6.2414
BibTeX
@article{agababyanirinarubenovna2026,
  title = {OPTIMIZED MULTICOMPONENT DRUG THERAPY WITH COLCHICINE IN THE PREVENTION OF ANGINA RECURRENCE IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION},
  author = {Agababyan, Irina Rubenovna and Kurbanov, Bekzod Kholmuminovich and Агабабян, Ирина Рубеновна and Курбанов, Бекзод Холмуминович and Agababyan, Irina Rubenovna and Kurbonov, Bekzod Xolmuminovich},
  journal = {Research Focus},
  year = {2026},
  volume = {5},
  number = {6},
  pages = {269-275},
  doi = {10.66073/researchfocus.v5i6.2414},
  url = {https://doi.org/10.66073/researchfocus.v5i6.2414}
}

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